Prevalence of Malignancies in Patients with Rheumatoid Arthritis and their Association with Biologic Disease Modifier Antirheumatic Drugs (BDMARDs)

According to Statistics Canada 2012, Arthritis is one of the most common chronic conditions affecting 4.4 million Canadians and 101.504 people in Newfoundland. It is also the most common cause of disability between the ages of 40 and 70 years. People with chronic arthritis have several numbers of other coexisting conditions such as high blood pressure, heart diseases, obesity. Precancerous lesions and cancer are a significant part of these coexisting conditions. Many reports suggest that inflammatory arthritis is associated with an increased prevalence of malignancies.

Redesign of Dental Preventive Formulations- Part I. Identification of Potential Remineralization Enhancers

Every day, people put their teeth at risk by eating foods that contain a lot of sugar. A lack of brushing teeth causes the build-up of bacteria. The bacteria use the sugars present in these foods to cause the weakening of teeth and if left untreated, can lead to holes and cavities in teeth. The concept of “re-mineralization” is the idea of using minerals such as calcium to make teeth stronger and have them heal faster.

A Needs Assessment for the Autism Spectrum Disorder Community in Newfoundland and Labrador

The objective of the project is to conduct a comprehensive needs assessment of the Autism Spectrum Disorder (ASD) population in Newfoundland and Labrador. While prevalence rates of ASD suggest that there are a large number of cases, the needs of this community are not well defined. Furthermore, we anticipate there will be significant differences in need in rural communities compared to urban centers and differences in needs across the age and severity spectrum.

Cytotoxic activities of novel formulation from Blue-O Medical Technology against pancreatic cancer cells

Pancreatic cancer is one of the most aggressive cancers with a very poor survival upon detection. Pancreatic ducts are channels responsible for secreting pancreatic juices into the small intestines to aid in digestion. Pancreatic duct cancers account for up to 80% of the total pancreatic cancers, and current treatment are not efficacious to control the progress of the disease. Preliminary results using new formulations from Blue-O medical show a specific killing of pancreatic cancer cells. In this project, we aim to determine the mechanisms of cell killing of the new formulation.

Sensors Western Operational Research and Development (SWORD)

Accurate monitoring of a patient’s vital signs – including body temperature, blood pressure, and pulse oxygenation – is central to the ability of clinicians to provide appropriate medical care. In spite of this, the standard equipment used to take these measurements is inefficient, inconvenient, and expensive. Adept Diagnostics will break into the medical device market with the development of novel wireless sensor systems to track these physiological variables continuously and inobtrusively.

iSpine: A Innovative Spine Image ProcessingToolkit

A versatile spine modeling toolkit would enable the automatic assessment of gross anomalies and the evaluation of limited regions and spine components such as vertebra and discs. The system would consist of modules for: 1) segmenting the spine; 2) modeling spinal components; 3) detecting, assessing and analyzing salient features; and 4) generating information for medical diagnosis, patient reporting and clinical management. Despite a clear need for a versatile spine assessment toolkit, none is commercially available today.

Child Strength: Supporting communities through executive functioning and early literacy strategies

It is evident that children require support for executive function and emergent literacy development to optimize their personal well-being, school, learning and life success. This project focuses on how to best support executive function [EF] and early emergent literacy [EL] acquisition for our children by providing a parent and early childcare community with strategies on how to engage and immerse young learners in developmentally appropriate activities.

Predicting disability benefits claim durations and Comparing actual versus expected disability benefits claim durations

The financial implications of time lost from work due to disability can be severe. Disability insurance coverage plans protect people from possible loss of income. We have found factors that predict the duration of disability benefit claims. However, it remains to be seen whether these associations are consistent. Improved understanding of modifiable factors associated with claim duration may help insurers optimize their case management processes to reduce overall claim durations, and facilitate more timely return to work.

The role of remote ischemic preconditioning (RIPC) in preventing organ dysfunction following hemorrhagic shock: a translational study

Dysfunction of vital organs is one major reason why trauma victims die after sustaining a major injury, even though the organs themselves may not have been directly injured. One intervention proposed to prevent development of distant organ injury is called “Remote Ischemic Preconditioning” (RIPC), wherein application of intermittent occlusion and release of blood flow to a limb by sequentially inflating and deflating a blood pressure cuff.

Local in situ Controlled Delivery of Biphosphonates in Bone Metastasis

We propose to develop in collaboration with Medtronic Canada a bioceramic drug delivery system for the local controlled release of Biphosphonates (BP) - drugs that prevent bone resorption - to promote both tumor inhibition and bone regeneration at the site of bone tumor resection, eliminating the need for high systemic doses and side effects associated with BP.

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