Investigation of adverse effects and healing factor properties of a novel formulation from Blue-O

The appearance of multidrug resistance of pathogens is challenging the researcher and industrial communities to develop more efficacious antimicrobial treatments. Blue-O Technology Incorporation (Blue-O Tech) has developed a novel formulation of medicine that accelerates the wound healing, while having an excellent antimicrobial strength over a broad spectrum of pathogens. The objectives of this study are to evaluate the cytotoxic effects, the immunological response, and the healing properties of this novel medicine prior to its marketing and commercialization.

Toward an understanding of how YB-1 regulates drug resistance in glioblastoma multiforme through epigenetic regulation governed by BMI-1

Glioblastoma (GBM) is the most common and aggressive form of brain cancers and is the second most common cancer in children only behind leukemia. Conventional therapy consists primarily of surgery, radiation, and chemotherapy, and while these approaches have slightly improved the length of patient survival, there remains no cure for this disease. With the emerging understanding of biology in the process of cancer development, identification of therapeutic targets are being elucidated that will allow more targeted and effective treatment of the disease.

Healing the body, healing the brain: Nutrition and exercise treatments for childhood neurodevelopmental disorders

In the absence of a clear set of recommendations from doctors for the treatment of neurodevelopmental disorders (NDD) such as fetal alcohol, cerebral palsy, and autism spectrum disorders, many parents and children affected by NDDs turn to unproven diet- and exercise-based treatments. While some research suggests that such interventions can boost brain functioning, very few studies of these programs look at their effectiveness for NDDs.

Retrospective molecular subtyping of pediatric medulloblastomas and the evaluation of BTIC gene signature in tumors with poor prognosis

Medulloblastoma is the most common brain tumor in children. It is treated with a combination of surgical resection, chemotherapy and radiation. Radiation to a child’s brain can have harmful side effects that may have implications in later development. We intend to use molecular gene expression to classify archived tumors into 4 subgroups with associated low and high risk. Along with this, we will analyze the expression of genes associated with a highly resistant subpopulation of cells called brain tumor initiating cells (BTICs).

Targeting the RSK axis to eliminate medulloblastoma

Brain cancer is the second most prevalent cancer in children. Current treatment options are chemotherapy, radiation, and surgery, which either prolongs the child’s life for only two years or leaves them with negative side effects such as slowed development. Thus, there is a pressing need for new therapeutics.

Atlas-based attenuation correction for PET/MRI

Positron Emission Tomography (PET) images need correction for the loss of photons. This loss, or attenuation, is due to interactions with patient tissues. Corrections are currently done with X-ray Computed Tomography (CT), however we are proposing a method whereby Magnetic Resonance Images (MRI) are used. This will be done by creating an attenuation map(?-map). The construction of ?-maps can be divided into two categories, patient specific ?-maps by MRI segmentation, and registration of a predefined atlas to an MRI.

Evaluation of a home transfer pole during assisted sit-to-stand in older adults with mobility limitations

Mobility in the home is a difficult task for older adults with mobility limitations and is associated with a risk of injury from falling. However, it is a requisite for maintaining independence. A number of assistive technologies have been developed to help a number of different activities of daily living, one in specific is the transfer pole – a vertically oriented pole that pressure fits between ceiling and floor and helps the user stand-up. Three common configurations include a single vertical pole, a single pole with a horizontal grab-bar, and two vertical poles.

SN-38 (or 5-FU) drug encapsulation in liposomes transported by magnetotactic bacteria for localized colorectal cancer treatment

 

Cancers are treated today with the appropriate combination of chemotherapy drugs, surgery and radiation. Chemotherapy is almost invariably dosed intravenously, and enters the systemic blood flow where it circulates around the whole body, coming into contact with healthy cells as well as cancerous ones. This systemic dosing has two big problems: too little drug gets to cancer cells, and too much drug comes into contact with healthy cells, causing side effects. Frequently, these dose-limiting side-effects prevent us from delivering the maximally effective anti-cancer drug dose.

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