Examining the Roles of Mouse Immune Cells in Liver Regeneration

The mammalian liver is known for its regenerative property, capable of fully restoring mass and function after injury. However, when this process is in disarray, chronic liver diseases occur, for which the current solution is liver transplantation. Transplantation remains an imperfect solution as the supply is limited and rejection can happen. Today, 25% of patients waiting for transplantation die before a liver becomes available. This study aims to describe a regenerating liver at the cellular level to explore the alternatives to liver transplantation.

Opioid Use in Pediatric-Onset Inflammatory Bowel Disease

Patients with inflammatory bowel disease (IBD) have an inflamed digestive tract and experience diarrhea, fatigue, and abdominal pain. Youth with IBD are six times more likely to take opioids than youth without IBD. We are currently in the midst of an opioid crisis. In 2016, there were almost 3000 deaths related to opioid use in Canada. This increased to nearly 4000 deaths in 2017. Since 2001, opioid-related deaths have increased by 345% in the United States. IBD patients taking opioids have a poorer quality of life, regardless of how severe their IBD is.

Towards the development of a bone substitute-based targeted drug delivery tool to treat bone metastasis

We aim to develop human bone extracts mixed with commercially available bone putty and prepare customized 3D print materials, both of which are infused with anti-cancer drugs. These bone substitutes could be used to fill and stabilize the large empty spaces and to locally deliver anti-cancer drugs that kills any remaining tumor cells and promote bone healing following tumor resection in patients with bone metastasis. We also aim to establish a 3D bone metastasis-like model that will be used to test the drug delivery from bone substitutes.

A robotic end-effector for surgical tool handoff

The goal of this research project is to establish a working robotic “hand”, or gripper, that will be able to perform surgical instrument handoff to operating room staff members during surgery. This project will involve a both McGill University and Kinova, the partner organization. Kinova will benefit from this project through increased collaboration with academia, as well as access to medical resources, such as surgical instruments, inquiries with medical professionals, or even observerships within operating rooms.

Publishing Dis/ability and Public Access

This project will investigate the creation of an accessible digital platform that will serve as the basis for all future publications of PUBLIC as well as a model for similar organizations looking to make the transition from print to digital. Importnatly, this project centers dis/ability communities, methods, and methodologies. Not only will this research situate PUBLIC and Public Access as a leader in digital publishing, but they will be providing access to a larger audience and be better equipped to work with dis/ability communities in the organization’s operations.

Development of a novel Saccharomyces yeast RNAi production and delivery platform

Heavy pesticide and antibiotic use are prevalent in modern agriculture and is an essential requirement to feed the ever-increasing human population. Their increased use, however, has also resulted in a loss of ecological biodiversity, environmental contamination, emerging pesticide/antibiotic resistance and is an economic burden to farmers, especially in low income nations. The research proposed aims to develop novel alternative agricultural bio-control technology centered around Baker’s yeast, a common and non-toxic organism used in baking and brewing.

Research into the Design and Development of Inclusive Digital Media Technologies

This project, a collaboration between Ryerson University and Pear Square, will be researching what would enable businesses and organizations to provide resources efficiently to students with disabilities. The outstanding issue is mainly a lack of standardized work flow methodologies that promote accessible development from the beginning stages of any project for large institutions. The research proposed for this project will be to formulate, test, and acquire feedback on experimental workflows that accommodate a variety of accessible digital media systems.

Low cost micro dispenser for general analytical or synthetic applications

The micro-dispenser serves to accurately and precisely dispense a variety of fluids in droplets with volumes in the microliter range. The micro dispensing is quite valuable as it reduces the required volume of reagents and subsequently reducing cost. Here we propose a novel micro dispensing technology based on electrowetting on dielectric (EWOD) digital microfluidic (DMF) technique.

Development of the Tat-GluN2BCTM peptide as a novel therapy for acute myocardial infarction

Acute myocardial infarction (commonly known as a heart attack) is a major disease of the cardiovascular system and a leading cause of death and hospitalization in North America. It results in 7.4 million deaths globally per annum. Current clinical medications only prevent the disease but cannot cure it after a heart attack occurs. Scientific evidence suggests that DAPK1 is a vital protein that can cause heart damage during a heart attack, and I have created a compound that is able to reduce the level of DAPK1 in the heart so as to prevent heart damage.

Radiofrequency Treatment for Emphysema in Rat Model

Emphysema, a lung disease that millions of Canadians currently suffer from, has few safe and non-invasive options available. One of the features of emphysema is the lack of proper blood flow in the diseased lungs and this results in poor gas exchange. IKOMED Technologies Inc. and the two interns will test an innovative technology that has the potential to remove diseased lungs non-surgically. Together they will test and optimize this application using small rats to check both safety and effectiveness of this new treatment method. IKOMED Technologies Inc.