Automated diagnosis of liver fibrosis and steatosis using deep-learning algorithms applied to conventional liver ultrasound

Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver disorders worldwide. NAFLD could lead to end-stage liver disease and considered as one of the most common causes of liver transplantation. Moreover, a large number of liver transplant recipients develop NAFLD after transplantation due to side effects of the medications that they have to use to keep their new liver healthy. Although liver biopsy has been used for a long time to evaluate the liver condition it is associated with a risk of bleeding and other side effects.

Effect of Diesel Exhaust Exposures on the Respiratory Microbiome in COPD Airways

Some of the bacteria present in healthy lungs protect the lung against harmful germs. Studies have shown that people with lung diseases often lack these "good" bacteria in their lungs. Our team has been demonstrated that breathing polluted air causes lung inflammation, which can make it hard to breathe, especially for people who have lung diseases. We think that polluted air could change the lungs’ bacteria.

Effectiveness of Cannabis strains at reducing seizure rate in a zebrafish model of epilepsy

Cannabis has been used for centuries to treat epilepsy and related convulsive disorders. While Anecdotal evidence suggests a therapeutic benefit in some patients, there is little information as to what compounds within Cannabis plants may have medicinal benefits. This work will highlight specific strains (which CEPG will grow locally in Jackson’s Arm, NL) that will potentially provide effective seizure control in epileptic patients.

Follow up of horses treated with stem cells at eQcell Inc.

For over 10 years, eQcell Inc. has been treating horses with stem cells. In order to efficiently direct future research, a full picture of the efficacy of past treatments is necessary. This project will follow up with all clients across 8 clinics to collect an up-to-date snapshot of previously treated horses’ health and progression or regression from the time of treatment. These data will help generate hypotheses and narrow the research focus of the company to where stem cells may be best applied.

Effectiveness of an electronic technique and adherence monitoring device on the clinical outcomes of patients with asthma: an exploratory pilot randomized controlled trial

Mobile health (mHealth) strategies hold a great promise to enhance treatment outcomes while mitigating health care costs. It allows health care providers to tailor treatments to each individual based on their lifestyle. The primary objective of this project is to assess the effectiveness of the BreatheSuite Metered Dose Inhaler device in improving the technique and adherence of inhaled medications among children with asthma.

Supporting Evidence-Informed Practice and Policy Making in the British Columbia Community-Based Paediatric Rehabilitation Sector

Community- based Physiotherapy, Occupational Therapy, and Speech Therapy for children and youth with support needs is delivered by non-profit agencies across BC that do not have access to resources and supports to ensure they are providing evidence-based practice. This research project will help the partner organization, BCACDI, understand how it can implement a system to effectively support these agencies.

Resili, a case study: An evaluation for improved user experience in DBT skills apps

This project seeks to build the body of academic understanding on how to effectively deliver a mental health skills-based intervention through a mobile app. The analysis will be done through retrospective and live analysis of the Resili app, a publicly available mHealth app which promotes strong mental health through the administration of a Dialectical Behaviour Therapy skills-based, self-taught curriculum. While there has been a recent flood of mental health apps, many have poor engagement rates, or administer interventions without a sound basis of evidence.

Brainstem Arousal System and Chemosensitivity: Novel measures, Modulations, and Relationships to SUDEP

Sudden Unexpected Death in Epilepsy (SUDEP), the commonest cause of death in epilepsy, is the most feared complication. SUDEP usually occurs following a seizure, most often in patients who are non-responsive to antiepileptic drugs. These patients are typically found dead in bed following respiratory apnea and cardiac arrest. Our group has shown that seizures in the brainstem are associated with cardiorespiratory failure and death. It is not known whether the fatal brainstem seizures impair the brainstem arousal system or if seizure directly impairs brainstem cardio-respiratory centres.

Application of multi-omics and pharmacological studies to discover potential new therapeutics for COVID-19

COVID-19 is the largest pandemic of the 21st century, affecting over 6.6 million individuals and claiming over 391,000 lives worldwide as of June 4, 2020. It is caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV2), which uses a receptor to gain entry into the host and cause active infection. This project involves the expertise of PROOF Centre and Professors Don Sin and Pascal Bernatchez.

Moving Beyond BMI: Cardiovascular fitness as biological marker of reproductive health

The Healthcare Foundation plays an active role in improving patient experiences across Newfoundland and Labrador. The significant findings from research funded by the Healthcare Foundation helps improve the way we diagnose and treat our population. After a grant is received a board member from the foundation is updated on the findings of the research, who then examines how the results will improve healthcare practices in the province. If our study yields significant results, offline resources may become available to the patient population, which can be accessed without seeing a physician.

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