Implementation of a chip-based MDTMA platform for evaluating prostate cancer treatment response and mode of action. - Year two

Prostate cancer is the disease of the old, effecting 1 in 7 Canadians with a death burden of 1 in 28. The management of the disease becomes extremely difficult with the development of the nonresponsive and aggressive form of the cancer. Thus, the clinicians are rendered helpless and hence there is an urgent need for the development of new targeted therapies. Response to chemotherapy drugs varies for every individual, leading to adverse effects in many. Hence every individual responds to chemotherapy drugs differentially, matching the right dose for individual patient is a big challenge.

Evaluation of Signal Mass as a new marker of brain tissue loss in multiple sclerosis

The degree of brain cell injury and death may be associated with disability and problems with memory and thinking skills in patients with multiple sclerosis (MS). This is most frequently measured by using magnetic resonance imaging (MRI) images to calculate shrinkage of brain volume. In fact, MS patients suffer more rapid shrinkage of brain volume compared to healthy people. However, brain volume can also fluctuate due to reasons other than brain cell death, such as water coming in and out of the brain.

Ultra-low power wireless sensor node design for health monitoring use cases

In this project we address the problem of power consumption for wireless sensor nodes. This is where among different components of a sensor, RF transceivers consume a significant amount of power e.g. approximately 80%. Hence the main objective is this project is to tackle the power consumption problem at the RF transmitter, where we aim to reduce the power consumption to micro-watts of power, with minimal sacrifice in achievable data rate and by keeping the connectivity range within an acceptable radius.

Expression of muscarinic receptors in neurogenic detrusor overactive (NDO) bladders of spinal cord transected (SCT) rats after preventive treatment with anticholinergic me

Following the study of spinal cord transected (SCT) rat models being treated by fesoterodine fumarate (antimuscarinic drug) to prevent neurogenic detrusor overactivity, bladders of all 30 animals were conserved. It was observed that an early fesoterodine fumarate administration at the time of transection modulates bladder overactivity. However, the exact mechanism of action is not known and should be investigated further focusing on detrusor muscarinic receptor modifications in order to support clinical trials with humans.

Evaluating the effectiveness of video as a medium of delivery and consumption of large quantity of digital information

The goal of the project is to evaluate the effectiveness of video as medium of delivery and consumption of large quantity of digital information. The team will create an automated way to generate videos for properties and rental information so as to reduce costs on manual video creation and build user profiles based on smart questions to present tailored information based on users’ needs in a video format. Through researching, implementing technologies, designing analytics tools and developing a prototype we hope to evaluate the effectiveness of dynamic video information delivery.

Understanding the cellular mechanisms sustaining functional capacity improvement with prehabilitation in colorectal cancer patients

Cancer is associated with weight loss, decreased muscle strength and inflammation. This has a tremendous impact on daily activity, autonomy and quality of life, involving both patients and care-givers. I previously worked on a preoperative intervention called ‘pre-habilitation’, a personalized exercise and nutritional supplementation delivered before surgery. The main idea is to prevent postoperative complications utilizing the time before surgery to put the patient in a better physical, nutritional and emotional state.

Proof of Principle Application for Biosensors in Animal Models

NXTSens has developed an implantable continuous monitoring, stand-alone and potentially mass-producible microsensor for accurate monitoring of tissue pressure and temperature in damaged limb muscles to better diagnose ACS. The proposed research will involve several sub-projects that include: i) develop appropriate surgical models for the accurate and reproducible placement of the microsensors in rodent compartments; ii) test the performance of a prototype microsensor in a relevant cadaver model.

Moving to Breathe, Breathing to Move: An interdisciplinary study on the benefits of choral and dance exercise for people with neuromuscular conditions

In this collaborative project with Muscular Dystrophy Canada (MDC), we will design and run choir singing and dancing programs for people with neuromuscular conditions, in order to study whether it improves their quality of life and their ability to breathe. Both singing and dancing have been shown to have significant medical and quality of life benefits for people with other kinds of disabilities, but little research has been done with those who have neuromuscular conditions. This will also be the first study to include participants who rely on ventilation technology to breathe.

Investigating the Change Management Process in High Performance Sports Organisations Related to Performance Management

Organisational change is part of life for sports teams, however, research suggests that despite how often change initiatives occur, the success rate for organisations achieving their desired outcomes is less than 30%.
The aim of the study is to investigate how top level sports organisations manage change and to compare the different approaches adopted by various sports in countries around the world.
This study will interview sporting directors and general managers from around the world in order to:
1) identify how sporting directors identify, research and plan change initiatives, with a compar

Using multivariate deep-learning algorithms for automatic quality control of high-resolution MRI - Year two

NeuroRx is an imaging contract research organization (CRO) specialized in the central nervous system (CNS) that utilizes state-of-the-art digital image processing techniques to produce accurate and precise outcome measures for clinical trials of drugs in development. Prior to analysis, all scans must pass Quality Control (QC). The goal of this project will be to incorporate advanced computer algorithms to automatically classify the quality of high-resolution structural brain Magnetic Resonance Images. The advanced computer algorithms will include deep learning algorithms.

Pages