Development of a Diclofenac Sodium Quick Kit for FoamaDerm™

The new regulations for pharmacies had catastrophic consequences for the ability of normal pharmacies to compound prescribed preparations for patients using drug powders. Most pharmacies have stopped to offer compounding services at all. This leaves a gap in the ability to provide timely access to needed medicines. The proposed research work will develop an individually packed drug solution which can be filled into compounding bases.

Perioperative Opioid Usage Quality Improvement [CDTS-PDF1] - Year two

Our aim is to use machine-learning to improve treatment of post-surgical pain in children and adults. Most people addicted to opioids were initially exposed through the treatment of pain from trauma and/or surgery. The opioid crisis is reaching the pediatric population, in whom effective post-surgical pain management, with less reliance on prescription of opioids, is more important than ever. Recent advances in machine-learning, combined with approaches to patient-oriented research, provide significant prospects for a learning health system.

Investigating WD repeat protein function in the nucleolar biology and cancer

Ribosome biosynthesis is one of the most multifaceted and energy-demanding processes in biology. It involves over 250 factors that transiently associate with the nascent pre-ribosome in a well-orchestrated manner. Importantly, increased ribosome biogenesis has a critical role in cancer initiation and progression. Owing to the advances in cryo-electron microscopy, this pathway's detailed mechanism started to be revealed, setting the grounds for new therapeutic interventions. The current project seeks to develop chemical probes for WD repeat proteins, a new drug target class.

Development of a lymphatic in-vitro model to study drug uptake

The lymphatic system serves an integral role in fluid homeostasis, lipid metabolism and immune control of the human body. Lipid based nano-carriers employing lymphatic voyage offer multitude of advantages like enhanced bioavailability, selective targeting to localized as well as metastatic conditions, controlled delivery and others. Lipid-based nano-carriers have been tested on various experimental various in-vivo, in-vitro, ex-vivo and in-silico models. The in-vivo models provide the best drug transport estimation, but they are both invasive and irreversible.

Development of alternative technologies to assess muscle functionality

Skeletal muscle is a dynamic tissue that undergoes many regeneration processes during our lifetime. Loss of skeletal muscle is known as muscle atrophy or sarcopenia and is directly related with quality of life and life expectancy. There are very few diagnostic tools to identify muscle atrophy and the ones available are time-consuming and expensive. Therefore, the most used diagnostic measure for accessing muscle atrophy and recovery is physical examination for patients with a certain mobility status.

Mobilizing public sector investments in vaccine R&D to address emerging viral threats

The COVID-19 pandemic reminds us that, first, global pandemics are significant threats to population health and material standard of living and, second, evidently not enough is being done to prevent pandemics. Future pandemics are likely if the system of pandemic preparedness is not improved. The first step to ensure we are ready for the next viral outbreak is to understand how the current system functions: who is funding this system and who is conducting the basic and applied R&D into diagnostics and vaccines? Which viruses are being targeted?

Establishment of an X-ray CT and FTIR mouse brain reference atlas

The intern will construct a 3D atlas of the mouse brain, constructed using multiple biomedical and chemical imaging techniques. The atlas will aid visualization of the 3D distribution of brain metabolites and biomolecules.. The atlas will be a powerful research and teaching resource with its multi disciplinary approach to processing and visualizing data collected at the Canadian Light Source (CLS) synchrotron. Biochemical imaging of the brain’s regional composition and metabolic processes will reveal new structural and functional information.

Chemistry, manufacturing, and control (CMC) assessment of Manganescan

To design effective and patient-specific cancer therapy, sensitive detection of relapse and distant metastases by non-invasive medical imaging is essential, for which MRI offers tremendous potential due to wide availability of the equipment in clinic and avoidance of ionizing radiation. Although gadolinium-based contrast agents are the most frequently used for MRI, they are associated with nephrogenic systemic fibrosis and brain deposition. Thus, less toxic manganese ions are exploited as an alternative for tumor detection using MRI.

Documenting Existing and Potential Models for Virtual Pharmacist Care in North America and Europe

The current pandemic has highlighted the need for utilizing virtual care in pharmacy practice to ensure accessibility to medication and pharmacist services while maintaining social distancing to limit the potential of contagion. As pharmacist virtual care becomes more prevalent, it is important to explore the various models that currently exist or are being developed. This project will aim to explore models of virtual pharmacy care that exists across North America and Europe.

Evaluation of PLO Micelles for Transdermal Peptide Delivery to Superficial Bone

This research aims to develop and test a transdermal delivery system for small bone healing peptide hormones. Peptides and many drug molecules do not usually penetrate the outer skin barrier, the stratum corneum, in order to treat the underlying body tissues. However, by using liposomal gel as a drug delivery medium, it is often possible to impart the transdermal delivery of several analgesic drugs, lipophilic hormones and even small peptides by using augmentative technologies.