Establishment of gut microbiota and impact on host immune function with early-probiotic supplementation in neonate calves

The neonatal and pre-weaned periods are the most challenging in dairy production, resulting in the highest mortality and morbidity rates, with diarrhea proving the most common cause of calf health problems. In order to treat and control this diarrhea, producers often rely on antibiotic therapy. An alternative is to provide living microorganisms (probiotics) that minimize pathogenic bacteria colonization of the gastrointestinal tract (GIT), without producing drug residues, when directly fed to animals.

The anti-Helicobacter pylori properties and mechanism of action of probiotic Lactobacilli secretomes

Helicobacter pylori (HP) is a bacterium that causes 65% of gastric ulcers and cancers worldwide. Current anti HP treatments often fail because the bacteria have become resistant and they have serious side effects. We are looking into using molecules produced by bacteria called Lactobacilli that are a natural component of the human gastro-intestinal flora to treat and/or prevent Helicobacter infections. The novelty of our approach is to focus on the molecules that Lactobacilli release (i.e. their secretions) and that could be administered to patients in a controlled and reliable manner.

Development of probiotic formulation to alleviate gut dysbiosis related to antimicrobial activity of several classes of psychotropic chemicals

Several classes of psychotropic compounds have been increasingly shown to possess antimicrobial properties with possible implication in microbiota-gut-brain axis. For instance, sertraline and paroxetine are efflux inhibitors in bacteria cell walls and are effective on gram-positive bacteria such as Enterococcus and Staphylococcus. Therefore, a comprehensive assessment of the antimicrobial effect of these chemicals on gut commensal bacteria and consumed probiotics will provide critical insight for the design of robust new nutraceuticals.

Analyzing the impact of the Lactobacillus rhamnosus R0011 secretome on intestinal epithelial cell and antigen-presenting cell interactions

Intestinal bacteria are now recognized as important for maintaining our health. Many questions remain about how these probiotic or health-promoting bacteria act to influence health, and how to use them to combat the numerous health problems associated with inflammation. The objectives of this research project are to determine how products made by one of these bacteria, Lactobacillus rhamnosus R0011, influence communication between certain cells important in our immune defences, intestinal epithelial cells and antigen-presenting cells. We have found that products of L.

Characterizing the role of probiotics in physiologically relevant ex vivo and in vivo models of infectious colitis

In the intestines of people living with inflammatory bowel diseases (IBDs), the balance of beneficial bacteria is shifted. Instead, the intestine is overloaded with potentially harmful bacteria – a phenomenon known as dysbiosis. This shift in bacterial populations is believed to be among the key contributors to the onset of inflammation observed in IBD patients.
Bioactive bacteria that help to re-establish equilibrium in the intestine are known as probiotics. They work by promoting the growth of beneficial bacteria while simultaneously warding off harmful bacteria.

Effects of probiotic treatment on maternal care and gut health, with outcomes for offspring stress resiliency

The care provided to children by their mothers is important for the development of a healthy stress response. Many things may affect the quality of a mother’s care, such stress, environment, and nutrition. Probiotics, a form of good bacteria found in the digestive system, have been shown to improve the wellbeing of offspring in rodents who are exposed to on-going forms of stress. We wish to investigate if probiotics improve a mother’s care towards her offspring, and the later ability of these offspring to respond to stress in a healthy way as they  develop in adolescence.

Effects of probiotic treatment on adulthood anxiety and obesity after exposure to Western diet

Scientific studies show that the connection between the gut and the brain affects obesity and anxiety development. Since exposure to stress increases these problems, the relationship
between stress and the gut-brain connection warrants investigation. In the proposed experiment, we will examine the impact of probiotic (beneficial gut bacteria) delivery on weight gain and anxiety in rats exposed to early-life-stress and a high fat and sugare diet.

Effects of a probiotic product from Lallemand Inc. on growth performance and intestinal morphology of chickens raised under suboptimal conditions

According to the Agriculture and Agri-Food Canada, Canada produced 1.2 billion kilograms of chicken with chicken products worth $2.5 billion. Domestic consumption of chicken in 2016 was 32.5 kilograms per person. Canada exported over 5.3 million chicks worth over $13.4 million, mainly to the United States. That same year, 134.1 million kilograms of chicken meat and edible bi-products, worth $453.1 million, was exported to 60 countries, with the largest importers being the United States and Philippines.

Finding innovations to improve calf gastrointestinal health

The neonatal and pre-weaned periods are the most challenging in dairy production, resulting in the highest mortality and morbidity rates, with diarrhea proving the most common cause of calf health problems. In order to treat and control this diarrhea, producers often rely on antibiotic therapy. An alternative is to provide living microorganisms (probiotics) that minimize pathogenic bacteria colonization of the gastrointestinal tract (GIT), without producing drug residues, when directly fed to animals.

Evaluation of probiotic bacterial strains for enhanced microbial biotransformation of polyphenol-rich potato extract

The proposed project searches to understand the effect of probiotic bacterial strains belonging to the Lactobacillus and Bifidobacterium genera on the degradation and bioavailability of phenolic compounds present in potatoes (Solanum tuberosum L.) after in vitro digestion. The more easily absorbed metabolites are associated with protective effects against cancer and diabetes mellitus type II. Additionally, the combination of probiotics with phenolic-rich potato extract may have beneficial effects on the human colonic bacterial composition.

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