Multiprong targeting with a combination of water-soluble CoQ10 and Ashwagandha extract to halt progression of Alzheimer-type neurodegeneration

The aim of the project is to develop a safe and nutraceutical-like formulation of UbisolQ10 (UQ), a unique water-soluble formula in combination with water-soluble Ashwagandha extract (AE), that can arrest the progression of Alzheimer’s Disease (AD). This novel formulation significantly increases bioavailability of CoQ10 and other compounds in the brain. This combinatorial treatment can target multiple mechanisms implicated in AD development including mitochondrial dysfunction, oxidative stress, inflammation and dysregulation of autophagy.

Development and tribological characterization of next generation ceramic materials for extreme environments

There are a lot of different challenges surrounding the aerospace industry and especially when it comes to the proper selection of materials in the design of long-lasting gas turbine engines. Various different materials options are currently available for the manufacturing of engines such as conventional metal, alloys and composite but their applications are limited in harsh environments due to their mechanical and tribological properties such as friction and wear.

Development of multifunctional coatings with antiviral and antimicrobial activity on hard surfaces, textiles and fabrics

Canada, like other countries, has been facing different challenges related to the spread of COVID-19. Since the starting of the pandemic, we all learnt that fomites (contaminated surfaces) can be one of the main sources of virus transmition. In this project we are proposing an innovative multifunctional coating with antiviral and antimicrobial activity to prevent the spreading through surface contamination. This will be done by developing a superhydrophobic coating with antiviral and anti-bacterial/anti-viral properties by releasing low concentrations of metallic ions.

Micron scale ultra-low-cost light emitting diodes made using silicon carbide semiconductor material

A next generation of silicon-carbide (SiC) -based high performance microLEDs has the potential to replace existing gallium-indium nitride-based LED used in LED illuminated displays. The development of these SiC microLEDs is the goal of this research in collaboration with display company AVT Solutions Ltd. Silicon and carbide are low-cost earth-abundant minerals with ?1% of the cost of gallium nitride.

Grid-aggregated Vehicle-to-Vehicle (V2V) Power Transfer: From Concept to Real-world Implementation

The aim of this project is the development of a novel approach, as to how e-mobility and charging needs are achieved through consideration of factors including mobility need, vehicle capability, charging capability, and facility capacity.

Detection of microbial and mammalian nucleic acids from complex solutions

The polymerase chain reaction is at the core of many health care diagnostic tests. This reaction, often known by its acronym PCR, involves the logarithmic amplification of DNA. When detecting the nucleic acids of RNA-based viral genomes PCR is coupled to a second step where the RNA is transcribed into single stranded DNA called cDNA.

Developing rapid and portable detection technology for monitoring manganese in drinking water systems

Manganese (Mn) is a contaminant of emerging concern in drinking water as a growing body of epidemiological evidence has identified adverse cognitive, neurodevelopmental and behaviour effects in children. Canada has been a global leader in advancing the regulatory framework for Mn in drinking water, and in 2019, Health Canada published a new drinking water guideline. For the first time, Mn is now regulated on a health-basis (i.e. Alberta and Nova Scotia).

Evaluation of Checkpoint Inhibitors Combination Strategies, Targeting TLR9-activation, DNA methyltransferase, and cytokeratin protein expression in Pediatric and adult neuroblastoma (NB) Using Novel Immune Competent Transgenic Mice Models.

Brain tumors are the leading cause of childhood cancer-related deaths. Similar to adult brain tumors, pediatric brain tumors are classified based on histopathological evaluations. However, pediatric brain tumors are often histologically inconsistent with adult brain tumors. Recent research findings from molecular genetic analyses have revealed molecular and genetic changes in pediatric tumors that are necessary for appropriate classification to avoid misdiagnosis, the development of treatment modalities, and the clinical management of tumors.

Rapid End of Line Testing for the Hydrogen Economy

The hydrogen strategy for Canada sets the target for hydrogen to provide up to 30% of the country’s energy demand by 2050. As technology and infrastructure development for the hydrogen economy advances, mass manufacturing practices to rapidly produce and test electrochemical cells at high throughput and low cost becomes of critical importance. The proposed research is envisioned to develop rapid end of line test methods that can detect a failure in an electrochemical stack within minutes, thereby addressing one of the major bottlenecks in the mass production of the hydrogen economy.

Design and Development of a Scalable EV Battery Tester/Emulator Including Health-conscious Cell Modeling

With e-transportation gaining traction within Canada (and N. America), the demand for superior battery performance over a range of operating conditions is garnering interest; especially over varied temperatures (-40ºC to +65ºC). The EV industry is finding it impractical to prove performance over a wide variety of state-of-charge (SOC) and state-of-health (SOH). Instead, testing can be performed using a single cell; however, this requires accurate SOC information, whereby the battery must be charged/discharged often, which is tedious.