Investigation of impact of technological advancement in positional MRI on measuring cerebrovascular reactivity

With the advancement of magnetic resonance imaging (MRI) techniques, an exciting time has emerged for research in the field of cerebral anatomy and physiology. The basis of this proposal is to employ a one of a kind imaging technique to drive forward our basic understanding of regional blood flow regulation in the human brain. The circulation of brain blood flow is profoundly influenced by the local prevailing pH (acid-base balance).

Cognitive Impairment Secondary to Depressive Symptomology and its Relationship with Functional Impairment

Depression is a disabling condition affecting millions of people. Some of the symptoms of depression make it impossible for people to function in their daily lives. People experience significant levels of memory, thinking, planning and other cognitive symptoms that impair their abilities to go to work, school and take care of themselves and family. What is unclear is how and to what extent does this type of impairment lead to real world disability, and whether or not these levels of impairment exist in a broad range of people with varying levels of depressive symptomology.

Understanding and Reducing Community-Based Personal Support Workers’ Risk of Occupational Injury

Personal Support Workers (PSWs) provide 70-80% of all paid home care. Unfortunately, community-based PSWs experience occupational injuries at more than twice the rate of the general population.

Budget impact analysis of Rapid Endovascular Treatment of Ischemic Stroke

The return on investment for medical imaging, interventional radiology, is not well understood, with limited existing research on the value realised from the funds spent. It is expected that the Hot Stroke Intervention by interventional radiologists will not only add direct value to the health care system but will have far reaching and significant impact on the Canadian economy. According to the Canadian Heart & Stroke, an estimated 62,000 strokes occur in Canada each year – one every nine minutes. More than 400,000 Canadians are living with long-term disability from stroke.

iMALDI-based Assays for Protein Activity to Improve Patient Selection for Therapeutic Akt Inhibitors in Cancer Treatment

Detailed profiling with modern analytical technologies has shown that most cancer types are composed of multiple small sub-populations with distinct molecular signatures. Correct identification of the cancer subtype can predict its response to a particular treatment. Genomics has commonly been applied for this purpose, but in some cases, our ability to predict drug response may be enhanced by instead measuring the drug’s direct protein target.

Investigation and development of plasma-based cancer diagnostic

The blood of cancer patients contains DNA that has been shed by their tumours (circulating tumour DNA or ctDNA). As such, any genetic mutations in the tumour may be detected in the patient's blood. Theoretically, patients can be followed and monitored through analysis of ctDNA, which would reveal if the patient is responding to treatment, is in remission, or if mutations are becoming more or less prevalent as the result of time and/or treatment pressure. The challenge is development of a reliable method of detecting ctDNA, with adequate sensitivity and specificity to guide treatment.

Analysis of a novel energy absorbing roof anchorage connector for fall protection in lower strength roof construction

There is a large need for anchorage connectors (AC) on low strength structural roofs. A patent-pending AC has been designed to provide a secure point for workers on lower strength roofs while having energy absorbing capacity to limit damage to the structure in the event of a fall. With the advent of more and taller wood frame buildings the need for AC for low strength structural roofs is paramount. Through this proposal we aim to develop the next generation of Energy Absorbing Roof AC through optimizing the materials and design for broad market distribution. Working in partnership with Dr.

Pilot Study of the Safety and Efficacy of Different Potencies of Vaporized Marijuana Participants with Chronic, Treatment-Resistant Posttraumatic Stress Disorder (PTSD)

This study is among the first studies examining the effects of whole plant herbal cannabis on a variety of outcomes, including mental health conditions, anxiety, mood, and sleep quality. The interns will gain valuable experience in the field of medical cannabis, and will collect important data on the effects of varying strains of cannabis on anxiety, mood, sleep, and general well-being. The benefits of this
program of research are expected to be far-reaching, to both Canadians suffering from mental health conditions and to the partner organization.

Diagnostic screening for conscious awareness in brain injury and disease: Visual component

Since the mid 1970s, medical personnel have used the Glasgow Coma Scale (GCS) as an important tool to rate and describe levels of consciousness. This scale is rudimentary and subjective, often resulting in misdiagnoses in cases where people lack the capacity to communicate. In some unfortunate situations, severe neurological damage can render people unable to move. Inevitably, these people are deemed vegetative when in actuality; many are simply ‘locked in’. For years researchers have used cognitive event related potentials (ERPs) with modified EEG to assess receptive language capacity.

Evaluation of the CACE Homecare Curriculum

In January 2016, the Centre for Ambulatory Care Education (CACE) at Women’s College Hospital completed the Homecare Curriculum. This online, simulation-based program is designed to help personal support workers, nurses, and rehabilitation professionals provide better care for older adults who wish to stay in their homes. The program presents learners with 3 virtual home environments and 3 patient profiles. Alone, or with a team, users navigate these virtual homes, learn about home-based care and complete quizzes that test their comprehension of the material.

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