Novel formulation for the treatment of interstitial cystitis

Interstitial cystitis is an inflammatory disease of the urinary bladder and is recognized as a serious medical condition associated with a profoundly negative impact on patients’ quality of life. Currently, there are no widely acknowledged causes of this disorder and no effective treatments available. Panag is a Halifax based drug company which focuses on development of novel therapeutic treatments which can be used to alleviate both pain and inflammation associated with IC. The goal of our research is to provide IC patients with symptom and pain relief, as well as to improve outcome.

Elaboration of a Phase II clinical study protocol for the treatment of metastatic non-small cell lung cancer (NSCLC) using AB-16B5, an epithelial to mesenchymal transition (EMT) inhibitor, in combination with docetaxel

The molecular mechanisms responsible for the occurrence of metastatic cancer are beginning to be elucidated with the identification of key regulators. Increasing evidence points to tumor cell epithelial to mesenchymal transition (EMT) as an important contributing process to metastatic evolution. The identification of factors that are stimulated during EMT might provide the means to develop new drugs required to increase the effectiveness of current regimens and improve patient outcome.

Small-scale Continuous Purification of Nanoparticles and Therapeutic Proteins

Our group developed a new generation of chip-based small-scale devices for continuous purification of chemicals and nanoparticles, based on the interactions of analyte with multiple types of driving forces in an electro-fluid-dynamic (EFD) system. One series of the purification devices has the electric field in parallel with the fluid flow direction (E?F), while the other series has two orthogonal driving force fields (E?F).

Efficacy of a novel anti-IL-1B receptor modulator in reducing preterm birth impact on neurovascular health - Year two

Preterm neonates ill-adapted to the extra uterine environment are prone to increased inflammation in multiple organs and the proinflammatory interleukine IL-1b has been closely implicated in brain injury associated with preterm birth (PTB). Notably, PTB survivors have a greater propensity to develop ischemic brain lesions long after birth. Here, we hypothesize that the neural vasculature of premature infants becomes irresponsive to hypoxic-ischemic stress.

Application of one-step affinity capture technique to purify Pertactin

Pertussis, also known as whooping cough, is a contagious bacterial disease that targets cells in the human respiratory tract. Whooping cough is an airborne disease that causes coughing fits, difficulty breathing and potentially death. Although it can be life threatening, the disease is preventable with proper immunization. Pertactin is a commonly used protein derived from the bacterial species, B. pertussis, used in the production of the vaccine against the disease.

Acetal-Free carbohydrate antigens and their multivalent display for lung cancer immunotherapy

This collaboration between pharmaceutical company NuvoBio and a Research Team led from the University of Windsor and working with Dalhousie and the University of Western Ontario seeks to develop a new vaccine for lung cancer. The students and postdoctoral fellows will be making new types of molecules and investigating some underlying questions about how we formulate vaccines, as well as preparing these promising compounds and studying their safety an efficiency in preventing and eliminating lung cancers.

Synthesis of an irreversible inhibitor of Pol?

One aspect of modern drug development involves understanding how enzymes function in terms of the progress of certain diseases in humans. This MITACS project involves the synthesis of small-molecule labels that can bind to a specific enzyme of interest, so as to better understand the mode of action of this enzyme as related to the progress of cancer. This work will involve the preparation of organic molecules possessing appropriate structural features that will enable selective and irreversible binding to the desired enzyme.

Total synthesis of anthocyanins for the prevention of cognitive decline

Alzheimer’s disease (AD) is an age-related neurodegenerative disease affecting more than >45 million individuals worldwide with numbers expected to reach >135 million by 2050. The multifactorial nature of AD hinders the development of therapeutic treatments and, as such, several drug candidates have failed in clinical trials. Polyphenolic compounds have the ability to reach the brain and target the multifactorial aspects of AD.

Development and characterization of nano-emulsification and liposomal platforms (NEP and LIP) for hemp oil nanoencapsulation and transmucosal delivery

A novel technology for delivery of biologically active compounds found in hemp oil is being developed. This novel technology significantly reduces the health risks associated with traditional administration of Cannabis products (e.g., smoking and THC-related intoxication) The proposed project, in collaboration with a federally-licensed facility for cannabinoid analysis, Abattis Bioceuticals, engages into the development of two different platforms for encapsulation of hemp oil using nanoemulsion and nanolipid carrier technologies.

Development of new therapeutics for castration-resistant prostate cancer treatment

Castration-resistant prostate cancer is a late stage disease and many people die of it due to lack of effective therapeutic drugs. In the current project, we propose to develop new therapeutic drug a to specifically target CRPC’s common weak points, which are MCT4 and eIF4E gene’s proteint products that play very important roles in regulation of cancer cell’s energetic and protein translation pathways. The project aims to develop an antibody drug, an small molecule chemical drug and a nanoparticle drug to target MCT4 membrane protein and eIF4E transcription factor protein.