The Pharmacokinetics Evaluation of HDAC6-selective Inhibitors for Use in Therapeutic Strategies

Histone deacetylase 6 (HDAC6) is a protein known to be involved in a wide array of cancers. Although there are currently 4 approved HDAC inhibitors to date, these drugs lack the selectivity to only target HDAC6, given its high structural similarities with 10 other HDAC proteins, resulting in severe side-effects in patients such as nausea, diarrhea, and cardiac toxicities. Moreover, these approved drugs are also easily eliminated by the body, requiring the patients to take high doses frequently, further worsening the toxicity profile.

Design of a Wearable Soft Sensor to monitor Skin Health

For people with mobility impairments, such as spinal cord injury survivors, rehabilitation and at home care settings come with the possibility of costly, painful pressure ulcers and skin breakdown. Occurring at a high frequency, current practice requires constant vigilance by caretakers and individuals using self-management practices. This injury comes from a prolonged application of pressures, temperatures and humid environments causing the skin to die from a lack of blood flow, usually from situations that an able-bodied person can avoid, but those with mobility impairments cannot.

Enhancing the charge speed, useable capacity, and cycle life of lithium-ion battery packs using a novel health-conscious fast charging and active balancing strategy

One crucial difficulty with fast charging lithium-ion battery packs is the possibility of battery capacity deterioration if not properly managed. Fast charging electric vehicles for example, should involve ensuring that each one of the thousands of cells are charged safely and are balanced to all the other cells if the range of the vehicle is to be maintained for several years. The most common way to safely charge and balance cells involves a lot of wasted energy and suboptimal capacity saving methods.

Design and Prototype of Hybrid Battery Management System (HBMS) to Supply Economic Energy Storage Solution in Ultra-Cold Climate

The battery is considered as the source of power for electric transport. The performance of the battery drops at low temperature which reduces the mileage of Electric Vehicle (EV). This issue is hindering the widespread adoption of EV in cold places like Canada. The Low-Temperature Battery (LTB) can be used in EV to solve the low milage problem in extreme cold temperature, but its cost is around three times higher than the Normal Temperature Battery (NTB). So, using the LTB in an EV is not economically feasible.

Cloud-based analysis platform for in-house DNA sequencing: plasmid validation

Biological manufacturers are now starting to make chemicals and biological products (like proteins) by growing large amounts of microorganisms like bacteria or algae. One major quality control step in the manufacturing process is to check the genetic sequences of these microorganisms because they often not correctly made. This is due to the biological method for manipulating the sequences is not perfect. To check that the genetic sequences are correct, manufacturers typically send samples for DNA sequencing at international service providers.

Intelligent Query and Learning System (IQLS)

Intelligent Query and Learning System (IQLS) is a web application that offers a platform for a business owner, product seller, service provider, doctor, engineer or anyone with a goal of providing service to their client or audience. Using this platform, an individual can train the system with information related to their business, service, or product, and the system becomes ready to answer related questions to their followers or audience who are interested in the service or product. Providing answers to the questions of the clients can help to increase sales and grow the business.

An image-guided, highly tunable hydrogel delivery device for novel minimally invasive therapies

Minimally invasive treatments have greatly changed the clinical landscape for a variety of disorders. A catheter is navigated through the body to the target site where a multitude of interventions can be performed, including drug delivery and therapeutic embolization and in the near future delivery of tissue-engineered constructs. However, there are still limitations for treatment safety and efficacy due to the less direct control physicians have over the diseased site compared to traditional surgeries.

Remediation and recovery of metals from mine effluents using genetically engineered microbial systems

Mines generate metal-contaminated wastewater that needs to be cleaned before it can be re-used by the mine or discharged into the environment. There are several ways to remove this metal, but many of these technologies are expensive and require non-renewable materials to work. Biological methods to remove these metals are promising renewable alternatives, but they have their limitations too: a lack of specificity for metals and the need to destroy the biomass to recover the metal for profit.

Improving glycerol utilization in E.coli for heme biosynthesis

Heme is a naturally occurring molecule found in our blood and as well as in animals, responsible for carrying oxygen throughout our body. Interestingly, heme has been commercially used in various products such as in cosmetics, nutraceuticals, and food. The traditional production of heme however often involves animal slaughter and harsh chemical processing, which is costly and ultimately limits other potential applications. The proposed project will investigate a different method of producing heme by fermenting microorganisms; much in the same way that beer, wine, and insulin are made.

Saccade Concussion Diagnosis System

The underlying technology will leverage artificial intelligence (AI) to analyze oculomotor (eye movement) data to learn and extract human translatable features/symptoms of concussion. The software is computationally light-weight that is capable of running on portable hardware with minimal computational power. The intern will examine the system's commercialization by conducting interviews with potential customers and identifying the additional critical features needed by end-users.

Pages