Targeting a complement serine protease in vascular disease

In spite of major advances in our knowledge and better treatments, heart attacks, strokes and blood clots in the legs and lungs, continue to major causes of disability and death. Recent studies reveal that a protein (a so-called "serine protease") in our blood, when increased, may heighten the risk of excess blood clot formation in our blood vessels. Our studies are designed to determine how this protein works, and if by blocking its activity, we can prevent excess blood clotting. Our research program may uncover a more effective way to prevent blood vessel disease.

Assessing the Market for the Finfish Vaccine

The aquaculture industry is growing rapidly worldwide and provides job opportunities as well as food for humans. However, diseases that are bacterial or viral, having a devastating effect on this sector. Every year huge economic losses are occurring due to bacterial diseases. Though there are several commercial vaccines available on the market, their efficacy is still questionable.

Investigating the effect of the Virtual Meditative Walk on brain in chronic pain conditions: A longitudinal fMRI study - Year two

The Virtual Meditative Walk (VMW) (1) is a well-developed therapeutic protocol that can be used alone or in combination with the Mindfulness-Based Stress Reduction techniques in an Immersive Virtual Reality (IVR) environment. It has been shown to be effective in reducing pain levels in patients with chronic pain (CP); however, little is known about how IVRs such as VMW may affect pain processing networks in the brain.

Investigating the mechanistic links between cannabinoid and pain-related gene variants and functional measures of musculoskeletal pain - Year two

Pain is a combination of mental, physical and social factors. This makes it difficult to understand and even more difficult to treat. Chronic pain is unique to the individual, and to treat it effectively requires a better understanding of how pain is generated in each person. The goal of this study is to describe the relationships between inherited genes and the factors that affect pain, recovery, and people’s response to medication. The first phase of this study has 2 aims. The first aim is to describe the relationship between genes, pain, and recovery time.

An integrated watershed-lake framework for water quality assessment in Toronto Harbour and Region Waterfront - Year two

This project aims to develop an integrated watershed-lake framework for Don River watershed draining into the Toronto Harbour to assess the best management practices towards improving the water quality in Toronto and Region Area of Concern (AOC). The framework will evaluate the impacts of suspended solids and bioavailable nutrients delivered by surface runoff and lake upwelling events on Toronto Harbour water quality, and their subsequent effects on eutrophication and growth of undesirable algae.

Anaerobic Bioaugmentation of a PHC Groundwater Plume: Pilot-Scale Experiment

Bacterial cultures are sometimes added to groundwater to increase the rate of degradation of contaminants. Three cultures that are able to completely biodegrade their primary compound to non-toxic end products in the absence of oxygen have been enriched from contaminated soils. The goal of this project is to demonstrate the efficacy of these cultures in a controlled field experiment. High resolution temporal and spatial data will be collected to estimate degradation rates, and support a process level understanding.

Improving the tools for assessment and analysis of energy losses through building envelopes using Infrared Thermography (IRT), Unmanned Aerial Systems (UAV), and Artificial Intelligence (AI)

IR imaging presents the temperature distribution of the exterior surface of a wall and is typically assessed through visual inspection by building science experts. A specialist must review numerous images one by one which is inefficient and inaccurate. The use of Unmanned Aerial Vehicles (UAVs) with IR camera attachments has become a method of faster and more accessible on-site building envelope evaluation. The proposed research aims to develop a machine learning framework to improve the evaluation of energy loss through the envelope, using UAV and IR thermography.

Advancing Controlled Environment Agriculture (CEA) Through 3D Printing Construction

A new process to create greenhouse glazing using 3D Printing is prototyped and tested. Using the principle of layer height fusion of plastic, new glazing will be created to provide shading and diffused light. The 3D Printed glazing will also be changed through the 3D Printer to change the amount of shading and diffused light, a benefit in hot climates.

Development of Smart Structural Control System for High-Rise Buildings Along the Coastline to cope with Extreme Loads

Civil infrastructures, particularly high-rise buildings, Along the Coastline are susceptible to damage when subjected to extreme loads like earthquakes, hurricanes, and tsunamis. These loads are associated with the tragic loss of life and high structural repair costs. Current research trends focus on developing design techniques to mitigate the adverse effects earthquakes have on structures. However, a major challenge with the current research trend is related to the high level of uncertainty in the actual response of structures during earthquakes (desired versus predicted response).

Spatiotemporal influence of sea cage aquaculture on wild fish dietary habits and biological characteristics

Research will involve capturing of commercially valuable wild fish species aggregated around sea cage aquaculture sites in different parts of Newfoundland, including one previously sampled. These specimens will then have samples taken that will be evaluated for an ‘aquaculture signature’ that would indicate direct or indirect consumption of sea cage feed and waste that becomes available to the local environment.