The impact of social environment on mobility status and occurrenceof falls in older adults. International comparisons

Human populations are aging all over the world and decline in mobility is an age-related problem that limits older adults' quality of life. One major risk factor for mobility disability in is falls. There are some modifiable risk factors for falls and identifying these factors can help public health professionals to devise proper prevention strategy.

Contributing to prostate cancer research in Canada

This desire to explore has led him to a Mitacs Globalink Research Internship at the Department of Physics, Engineering Physics and Astronomy at Queen’s University this summer.

Automatic crack detection in stamped auto-parts

The objective of the project is to develop a non-destructive test protocol to accurately and reliably detect cracked, pre-welded automotive parts within the constraints of an industrial assembly cell. This will involve reviewing, developing and testing one or more test procedures based on vibration excitation of the part and the measurement and analysis of the response.

Development of an Accurate Method for Predicting Heat Transfer in Screw Conveyors

The aim of this project is to develop an accurate numerical method of predicting the performance of screw conveyors in which there is heat transfer to or from the material being transported. A detailed review of past studies in this area will be undertaken and based on this and on an understanding of the characteristics of the software that will be used a solution procedure will be selected. This procedure will be implemented using the commercial software package FLUENT©.

Characterization and application of multidimensional coherent imaging systems for monitoring and control of laser welding

Inline coherent imaging (ICI) may be used to take real-time one dimensional measurements of laser material processes such as industrial laser welding. Multidimensional coherent imaging and measurement of the vapour capillary (or 'keyhole') created during the welding process is a critical evolution of the technology for implementation in manufacturing production addressing many needs. This project will investigate and attempt to implement multidimensional ICI in an imaging system for real world applications.

Towards the commercialization of an infrared-heated sample introduction system and development of an argon recycling system for inductively coupled plasma optical emission spectrometry (ICP-OES)

Numerous industries and government agencies carry out analyses every day using inductively coupled plasma (ICP) instruments that typically waste 95% of the sample and consume large amounts of argon. A greener approach would not generate any sample waste and reduce expensive argon consumption. The first year will be devoted to making a viable commercial product from an infrared-heated sample introduction system for inductively coupled plasma optical emission spectrometry (ICP-OES). If the prototype can be developed as a financially feasible product, the company would patent it.

Further investigation of Paced Electrogram Fraction Analysis (PEFA)

The goal of this project is to develop a faster and more accurate way to detect ventricular tachycardia using an algorithm to analyze the signal results from Paced Electrogram Fractionation Analysis (PEFA); ideally real time through use of a basket catheter. St Jude Medical, our research partner, creates medical hardware specifically geared towards detecting and treating heart disease, including arrhythmia. If we are successful in our endeavor, they hope to gain an improved diagnostic system.

State-society relations at the margins: Control and Resistance in Turkey’s borderlands (1990-2004 and 2004-present)

There is a controversial relationship between the levels of democratization and violence. Although it is assumed that more democratic a country becomes less violence occurs, there are some counterarguments (Tezcur 2009). This project is an attempt to test the viability of whether democracy leads pacification. We will compare two time periods to evaluate the impacts of change in state strategy toward Kurds in Turkey’s borderlands. The first is the period from 1990 to 2004, which is a period of military domination. The second time period is commonly associated with political liberalization.

Investigation of In-Situ Flux Effect on Hydride Properties in Zr-2.5Nb Pressure Tubes in CANDU Reactors Year Two

Zr-2.5Nb pressure tubes used in CANDU reactors are susceptible to hydride cracking-induced crack initiation mechanisms, a.k.a delayed hydride cracking or DHC and overload crack initiation. For the integrity assessment of CANDU pressure tubes, it is required to evaluate the likelihood of DHC and overload crack initiation from serviceinduced flaws and to determine whether the pressure tubes are still fit for continued service. The main focus of this proposal is to evaluate the effect of in-situ flux effect on the structure and fracture properties of zirconium hydrides.

Design and Synthesis of Specific Inhibitors of CYP26 for Blocking Retinoic Acid Metabolism: A Safer Approach to Retinoid Therapy for Skin Disease Year Two

Acne is a common human skin disease which is highly prevalent during adolescence, and often continues into adulthood. Retinoids, such as isotretinoin (Accutane/Roaccutane), have been particularly effective systemically in the treatment of acne. Although, millions of patients have been treated with Accutane/Roaccutane which for many years generated more than $1B U.S. in annual sales, the side effects, such as birth defects and inflammatory bowel disease, can sometime be severe. The market opportunity of an effective treatment with a better safety profile than isotretinoin is significant.