Further investigation of Paced Electrogram Fraction Analysis (PEFA)

The goal of this project is to develop a faster and more accurate way to detect ventricular tachycardia using an algorithm to analyze the signal results from Paced Electrogram Fractionation Analysis (PEFA); ideally real time through use of a basket catheter. St Jude Medical, our research partner, creates medical hardware specifically geared towards detecting and treating heart disease, including arrhythmia. If we are successful in our endeavor, they hope to gain an improved diagnostic system.

State-society relations at the margins: Control and Resistance in Turkey’s borderlands (1990-2004 and 2004-present)

There is a controversial relationship between the levels of democratization and violence. Although it is assumed that more democratic a country becomes less violence occurs, there are some counterarguments (Tezcur 2009). This project is an attempt to test the viability of whether democracy leads pacification. We will compare two time periods to evaluate the impacts of change in state strategy toward Kurds in Turkey’s borderlands. The first is the period from 1990 to 2004, which is a period of military domination. The second time period is commonly associated with political liberalization.

Investigation of In-Situ Flux Effect on Hydride Properties in Zr-2.5Nb Pressure Tubes in CANDU Reactors Year Two

Zr-2.5Nb pressure tubes used in CANDU reactors are susceptible to hydride cracking-induced crack initiation mechanisms, a.k.a delayed hydride cracking or DHC and overload crack initiation. For the integrity assessment of CANDU pressure tubes, it is required to evaluate the likelihood of DHC and overload crack initiation from serviceinduced flaws and to determine whether the pressure tubes are still fit for continued service. The main focus of this proposal is to evaluate the effect of in-situ flux effect on the structure and fracture properties of zirconium hydrides.

Design and Synthesis of Specific Inhibitors of CYP26 for Blocking Retinoic Acid Metabolism: A Safer Approach to Retinoid Therapy for Skin Disease Year Two

Acne is a common human skin disease which is highly prevalent during adolescence, and often continues into adulthood. Retinoids, such as isotretinoin (Accutane/Roaccutane), have been particularly effective systemically in the treatment of acne. Although, millions of patients have been treated with Accutane/Roaccutane which for many years generated more than $1B U.S. in annual sales, the side effects, such as birth defects and inflammatory bowel disease, can sometime be severe. The market opportunity of an effective treatment with a better safety profile than isotretinoin is significant.

Cytokine profile in women with cervical insufficiency

Cervical insufficiency (CI) is a condition in which the cervix prematurely shortens and dilates during pregnancy, typically resulting in mid-trimester pregnancy loss or premature labour. The causes of CI are currently unknown. However, recent studies have associated abnormalities in immune system regulation with pregnancy complications such as spontaneous abortion and premature birth. Since the immune system is regulated by circulating molecules known as cytokines, abnormal cytokine regulation could be associated with these pregnancy complications and with cervical insufficiency.

Cooperative Integrated Navigation Systems for GNSS-Challenging Environments

Connected Cars is an emerging technology that aims at enhancing driving experience and improving safety, productivity, and integrity of transportation systems. Intelligent Mechatronic Systems Inc. (IMS) is a leader in telematics and infotainment technologies, including the convergence of both technologies in delivering the ultimate connected car experience. One of the core components in connected cars environment is an accurate and robust positioning system that can work in all environments. Current location technology is dominant by the popular Global Positioning System (GPS).

Novaxe: Novel Online System for Guitar Music Score Recognition, Retrieval, Presentation, and Animation

This project is going to digitalize a patented method of presenting the guitar tablature and build an online system to assist guitar teaching. The new method can present the guitar tablature with 8 building clocks. People can easily learn the chores of thousands of songs, which is impossible with the other methods. The system is called Novaxe. Novaxe is going to have a graph screen to display the fretboard with the information about the chord progression, rhythm pattern, tempo, key, `position`, song form, chord form, title, artist, year, and genre of a song.

Image-objects Manipulation Engine (IoME): semi-automated feature extraction from Very High Resolution (VHR) remotelysensed imagery Year Two

Features identification and extraction from remotely sensed (RS) image is an ongoing research endeavor and has wider applications. Traditionally it has been based on pixel-based image analysis which has proved to be inefficient and ineffective especially for very high resolution (VHR) data. More recently object-based image analysis (OBIA) has gained a wider recognition because of its potential for accurately extracting objects from RS data corresponding to real-world features.

Image-objects Manipulation Engine (IoME): semi-automated feature extraction from Very High Resolution (VHR) remotelysensed imagery Year Two

Features identification and extraction from remotely sensed (RS) image is an ongoing research endeavor and has wider applications. Traditionally it has been based on pixel-based image analysis which has proved to be inefficient and ineffective especially for very high resolution (VHR) data. More recently object-based image analysis (OBIA) has gained a wider recognition because of its potential for accurately extracting objects from RS data corresponding to real-world features.

Design and Synthesis of Specific Inhibitors of CYP26 for Blocking Retinoic Acid Metabolism: A Safer Approach to Retinoid Therapy for Skin Disease

OBJECTIVE; We will advance our development of novel specific inhibitors of the retinoic acid (RA) metabolizing P450 enzymes, CYP26A1 and CYP26B1, to treat skin disorders - an approach that will have significant safety advantages over current retinoid therapies. These inhibitors will be used primarily to target cystic acne but will also be evaluated for their therapeutic potential in treating other skin disorders including actinic keratosis, rosacea, oral leukoplakia and skin cancer.

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