Drug models describe the relationship between exposure (or pharmacokinetics), response (or pharmacodynamics) for both desired and undesired effects, and individual patient characteristics. In this project, drug models will be used to propose an integrated dose adaption strategy for cancer treatment. This strategy has a particular clinical value for our partner (InVentiv Health Clinical, a Contract Research Organization) because it would allow to better inform of the drug development process, thus reducing studies´ cost, drug development duration and risks in a long run.
Les données qu'on rencontre aujourd'hui sont souvent de grande dimension. Avec les données génétiques, les signaux et les images, des méthodes d'analyse qui tiennent compte de la taille des données est plus que jamais nécessaire. Chez Hydro-Québec, une nouvelle méthode de surveillance des équipements électriques a été développée, qui fait appel à la théorie de la communication. Cette méthode a mis en évidence l'utilité de tenir compte du comportement des données aléatoires dans un espace de grande dimension, bien connu en théorie des communications.
Osteoarthritis is a chronic painful disease of joints that involves the progressive destruction of the articular cartilage and bone and leads to pain. It affects both humans and animals. Animals can serve as models for the human disease and in this case we will study equine OA. There is currently no effective medication that can effectively reverse the cartilage destruction in OA. This is mediated by enzymes. It was believed to be due to MMP enzymes alone until recently we showed that Cathepsin K is also involved.
Streptococcus suis is one of the most important causes of bacterial disease in post-weaned piglets. Affected animals suffer from meningitis (affected brain), endocarditis (affected heart), arthritis (affected joints) and septicemia (general infection). There are 35 serotypes of S. suis (same bacteria but different antigens). Some of these serotypes (such as serotype 2) can also affect humans (transmission from pigs), causing serious disease. Usually, veterinarians use antibiotics to treat and even protect animals.
Le projet vise à concevoir un système informatique en mode Saas (Software as a service) qui permette de réaliser de façon automatique et autonome le diagnostic des processus d’une PME pour vérifier son niveau de conformité à une réglementation, la production de recommandations personnalisées en fonction de l’entreprise, de ses besoins, de ses processus et de son contexte d’affaires, la certification de conformité après l’implémentation des recommandations.
In the context of the intern’s postdoctoral project, the research project aims to examine the correlation between the restrictiveness of a reform and the likeliness of its transfer using the IMPALA database. To this aim, the intern, after having received appropriate training, will incorporate the relevant regulatory framework in the International Migration Policy and Law Analysis (IMPALA) database. The IMPALA database includes a wider range of regulatory documents than existing databases, with primary and secondary legislation, administrative directives and relevant case law.
With the support of Pierre des Lierres, Business Development Director at Mitacs, the company obtained the financial support of Mitacs Accelerate Quebec and connected with Iban Harlouchet and Professor Pierre Lafaye de Micheaux from the Department of Mathematics and Statistics at Université de Montréal. Iban undertook research at Odotech to optimize algorithms of the e-nose sensors that analyze olfactory emissions.
DHEA is a major neurosteroids precursor, and a decrease in its serum levels have been associated with neurodegenerative diseases, especially Alzheimer's disease. Little is known about steroid hormones localization and levels in the major functional areas of the human brain and which enzymes are involved in their synthesis and inactivation. We will investigate steroids levels in these areas using matrix-assisted laser\ desorption/ionization (MALDI)-Imaging mass spectrometry and liquid chromatography coupled with tandem mass spectrometry using the monkey brain as model.
In this project, we propose to develop innovative methods to improve the efficiency of yard operations in intermodal terminals where containers awaiting to be loaded on the trains are temporarily stored. The management of yard operations involves allocating storage space to containers on the yard, and assigning cranes and/or other handling equipment to transfer the containers to the rail cars. The lack of proper planning and mishandling of containers can lead to large delays and significant rise in the operating costs.
The goal is to investigate the realistic appearance models for complex reflectance properties, modeling reflectance, masking and inter-reflection at many scales. In the end, comparison and basis-space representation will be leveraged to develop an interactive rendering application for pre-visualization and in-game portrayal of complex materials.