Cancers are heterogeneous disease that hijack many of the body’s normal biological processes. Additionally, tens of thousands of genes are involved in each person’s normal biology, while only a fraction of those are repurposed by cancers to drive disease. At an individual level, utilizing entire transcriptomes is rare, as there is too much information for clinicians to process. However, not using this resource can mean important genes and processes are missed. Identifying the set of genes that drive a patient’s cancer would improve therapy design, patient quality of life and outcomes.
The proposed initiative is different from conventional small molecules or biologics therapies. The living “drugs” are patients’ own immune cells. However, due to factors, such as age, and genetic differences between individuals, there is no magic “one treatment for all patients”. Intrinsic interpatient heterogeneity requires “personalized immune-therapy”. We have to adopt a “quality control” when we re-engineer immune-cells.
As very large scale integrated circuit (VLSI) technology progresses, power consumption and power density of VLSI circuits increase when design complexity and transistor density increase. Low-power design becomes a major design challenge. Lowering the supply voltage is one of the most efficient ways to save power because power consumption is proportional to the square of supply voltage. Electronic devices are expected to operate at much a lower supply voltage than traditional designs, which is very useful for portable electronics and biomedical implants.
The project will entail the production and characterization of hydrogen silsesquioxane (HSQ), a useful material for both lithography and production of silicon nanomaterials. This material is the workhorse for Applied Quantum Materials Inc. (AQM), as it is one of their central products that they supply to the e-beam lithography industry as well as the precursor for their silicon nanomaterials.
Ethylene is an important building block for the chemical industry and is most widely produced at global production scale of 200 million metric tonnes. As a typical chemical feedstock, ethylene is used to produce plastics, consumer goods, solvents, paints, among many others. Ethylene is predominantly produced by steam cracking which is run at very high temperatures and releases up to 2.7 kg CO2 eq./ kg of polyethylene produced. In Alberta, the production of ethylene and derivatives results in more than 4.5 million tonnes CO2 eq.
The proposed research deals with automating of screw-propelled unmanned ground vehicles. This type of vehicle is capable of traversing any ground from hard to soft to water. Copperstone Technologies, an Edmonton, AB-based startup, has developed a series of human-piloted versions of this vehicle and used it for missions such as water sampling and surveying of bodies of water. The proposed research will be to develop onboard software to enable the vehicle to perform its missions autonomously, reducing operator tedium and increasing efficiency of the operations.
The impact of COVID-19 on the mental health of women is currently unknown in Yukon Territory. Women have experienced unemployment, domestic violence and greater caregiving responsibilities because of COVID-19. It is important to support women's mental health during the pandemic. Therapeutic Recreation is a healthcare profession that uses leisure and recreation to improve health and wellbeing. Therapeutic Recreation provides positive leisure experiences that can reduce the impacts of C19 on women’s mental health.
This project is designed to characterize the effect of flocculant addition to mine tailings for the reduction of mine dust dispersion. Mine dust prevention is of importance for mine management as well as to reduce the possible dispersion of dust to nearby urban centers like Timmins and Porcupine Lake. To assess the effect of flocculation, we will use collected micrometeorological data as well as tailings material characterization to parameterize wind erosion and dispersion models. The project results will help provide recommendations towards the development of a dust emission management plan.
This research aims to develop and test a transdermal delivery system for small bone healing peptide hormones. Peptides and many drug molecules do not usually penetrate the outer skin barrier, the stratum corneum, in order to treat the underlying body tissues. However, by using liposomal gel as a drug delivery medium, it is often possible to impart the transdermal delivery of several analgesic drugs, lipophilic hormones and even small peptides by using augmentative technologies.
Corona Virus 19 creates adverse effects on the global health system leading to economic crisis. Although trials to develop vaccines are underway, it would take a while for the general public. Wearable sensors have been receiving increased attention toward monitoring the wearer’s well-being and playing a significant role in the healthcare industry. The upper respiratory tract is the first site for hosting and transmission of COVID infection. Therefore, developing a wearable nasal sensor will achieve in-home continuous monitoring of virus in the nasal cavity.