Impact and Vulnerability of Caribbean fisheries

Marine fisheries are complex, multifaceted endeavors that are deeply interconnected with both the ecological and social systems within which they operate. To manage a given fishery resource effectively, practitioners have account in the past years for ecological interactions with other marine species and socio-economic interactions with commercial and subsistence harvesters.

Development of Advanced Comminution and Gravity Concentration Technologies for Low Water and Energy Consumption

Mineral extraction and processing by mining operations is land, energy and water intensive. Mineral processing is both the single largest end-use of electricity, as well as the most water-intensive stage in the mining value chain. This research will help to tackle the issues of power and water consumption and lead to the development of reductions in land, energy and water intensity at mining operations.

Development of a commercial protocol to differentiate human pluripotent stem cells into skeletal muscle progenitor cells (hPSC-SMPCs) with transplantation potential

Recent scientific breakthroughs have led to the development of methods to differentiate human PSCs (hPSCs) into skeletal muscle cells. This has allowed, for the first time, the development of cellular models to study muscle diseases such as Duchenne Muscular Dystrophy and the possibility to utilize these cells for cell therapy applications. However, the reliability, efficiency and prober characterization of cells produced from these differentiation protocols remains a roadblock for their routine utilization by the research community.

Strategic BC Salmon Health Initiative: effects of pathogens on the health and conservation of BC’s Pacific Salmon

B.C.’s Pacific salmon are in decline yet the causes are not clear. The role of disease in declining productivity is poorly understood but is potentially an important factor especially given recent controversies involving salmon farms and disease transmission to wild salmon. We have recently collected quantitative data on 47+ viral, bacterial, fungal, and protozoan pathogens in >16,000 out-migrating juvenile sockeye, Chinook and coho salmon and 4,500 salmon from farms culturing Atlantic and Chinook salmon.

Simulation and Analysis of Aerators at Fish Farms

Fish farms are a way to satisfy the increasing demand for fish without directly impacting wild stocks. In fish farms water quality significantly impacts fish health and development. Industrial fish farms rely on aerators for multiple purposes, including the oxygenation of water and the isolation of fish from plankton blooms. However, at this time, several critical aspects of aerators are not completely understood. This study will be conducted in several stages, with a combination of experimental and simulation techniques.

Novel Additives to Enhance the Delivery of Foliar Crop Sprays

Crop yield is increasingly important for feeding the global population and making Canada a more self-sustaining country. Active AgriScience is a BC based company that is developing novel technologies and formulati,ons for improving yield in many types of crops including canota, wheat, com, barley, and others. One of the key services that !\clive AgriScience offers is the ability to combine a number of agrochemicals into a single formulation, while maintaining the stability and benefits of each individual ingredient.

Cited: Partnered Knowledge Mobilization Between Research and Media Organizations

This is project that creates audio documentaries that are grounded in academic research. As part of this project, Mitacs interns will work for three distinct podcasts: Cited Podcast, Crackdown, and Blue and Goldcast. These podcasts are meant for a general audience, and have wide popular and critical appeal. They are developed in a unique collaborative approach (putting students, scholars, and professionals together), which makes for a compelling final product. Mitacs interns will conduct original research and reporting to support the development of these podcasts.

The potential effects of a carbonic anhydrase IX (CAIX) inhibitor, SLC-0149, on AD pathogenesis

Alzheimer’s disease (AD) is the most common neurodegenerative disorder. SignalChem LifeSciences Corp. recently developed a potent small molecule inhibitor (SLC-0149) for targeting CAIX, a hypoxia inducible gene, in the application of treating cancers. Since hypoxia has been implicated as a factor to facilitate AD development, this study aims to explore the potentiality of applying SLC-0149 to treat AD model mice. More specifically, we will focus on the effects of SLC-0149 on two neuropathological features in AD, including A? deposition and Tau phosphorylation.

Evaluation of Phytosanitary Measure Efficacy Using Genomics

In recent years, globalization and increasing international traffic have allowed tree infecting micro-organisms and pests to colonize new forests and plantations. These invasions are a threat to global trade and the delicate ecological balance of our forests. Good examples are the Sudden Oak Death (SOD) outbreak caused by Phytophthora ramorum in California and the emerald ash borer in eastern Canada. Such epidemics can wreak havoc and halt international trade resulting in loss of millions of dollars.

Small-scale Continuous Purification of Nanoparticles and Therapeutic Proteins

Our group developed a new generation of chip-based small-scale devices for continuous purification of chemicals and nanoparticles, based on the interactions of analyte with multiple types of driving forces in an electro-fluid-dynamic (EFD) system. One series of the purification devices has the electric field in parallel with the fluid flow direction (E?F), while the other series has two orthogonal driving force fields (E?F).

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