Evaluation of corticosteroid-releasing nano- and micro-particles for pain management in osteoarthritis

Osteoarthritis is a progressive joint disease that causes pain and stiffness, resulting in a decrease in quality of life for patients. Treatment include intra-articular administration of crystalline corticosteroids or hyaluronate. Intra-articular corticosteroids, due to the large doses required, short residence time in the joint, and crystalline structure, are associated with cartilage damage and a short duration of action requiring multiple injections.

“Stem-cell based therapies: potential of human drNPCs transplants as treatment for spinal cord injury”

Currently no regenerative therapy exists for spinal cord injury. This project aims to optimize and generate the ideal cell type for stem cells to be used to treat cervical spinal cord injury. It aims to do so by testing the transplantation potential of different derivatives of the cells responsible for formation of neurons and other supporting cells within the spinal cord and central nervous system – the neural precursor cells (NPCs). The study will be performed on rodents and will simultaneously optimize the most suitable method to deliver the cells to the site of injury.

Integrating the User Perception and Experience into the Planning of Automated and Connected Electric Shuttle Services in Canada

The project will provide an opportunity to address key challenges related to user expectation of Automated and Connected Electric Shuttles. That is, the project will serve to advance the understanding of user perception and experience of smart shuttles in Canada. This technology is increasingly often being tested in pilots across Canada and it is critically to proactively understand the reaction of residents to this new technology.

Dental Materials for Ultra-Long-Term Caries Prevention

Tooth decay (dental cavities or caries) affects over 90% of the population worldwide, however their treatment with "white" resin composite fillings yields significantly worse results than classic metallic fillings. Caries-causing bacteria penetrate the space between tooth and filling, causing further tooth decay. This damage must be treated by removing the previous filling and diseased tooth tissue, and subsequently re-filled. We have developed novel antimicrobial microspheres that are loaded into the dental filling material, preventing bacterial infiltration for the patient’s lifetime.

Evaluating the Co-Translational Framework for systematic translation of scientific knowledge towards implementation

The University of Toronto’s Translational Research Program (TRP) is a graduate program that developed the Co-Translational Framework (CTF) to systematically mobilize research towards innovations to improve health outcomes.
The Translational Research for Innovation initiative is the research mechanism to help validate the CTF to facilitate meaningful collaboration between industry and academia.

# Fearlesslearning: Engaged and Included in a STEM Virtualized e-Learning Environment

There is a rapidly growing disconnect between what schools and education can provide and the conditions students need in which to be empowered in a rapidly changing world where innovation will be a necessary skill for all students to thrive in the future. This proposed research project is expected to bridge the gap between industry, educator, parent and child. The expected benefit to STEM Minds Corp.

Dissecting fibroblast-macrophage-T-regulatory cell communication in the fibrotic niche

Idiopathic pulmonary (lung) fibrosis (IPF) affects 5 million people with a mean survival time of 2-3 years after diagnosis. In lung fibrosis, connective tissue fibroblasts excessively produce and stiffen collagen matrix. The resulting scar destroys the delicate lung architecture, decreases lung compliance and gas exchange, ultimately rendering patients unable to breathe. The only effective treatment for IPF patients is a lung transplant. Typical of lung fibrosis is the chronic co-existence of fibroblasts, innate immune macrophages, and adaptive immune T-cells.

Evaluation of corticosteroid-releasing formulations to suppress implant device- related foreign body reactions and fibrosis

Implanted medical devices have dramatically improved the lives of millions of patients worldwide. However, in many cases, the body’s immune system rejects these devices and encapsulates the implant in fibrous scar tissue. This reaction is most detrimental to sensors for continuous monitoring and treatment of chronic conditions such as diabetes and those of the central nervous system. Device functionality is usually severely limited and risky additional surgeries for implant removal and reinsertion are required.

Evaluating the health of primary human airway epithelial cell cultures grown at air-liquid interface

There are many ways for scientists to study lung diseases.  One way that scientists try to understand lung disease is by growing and examining lung cells in the lab.  While most cells are grown submerged in special liquid that provides the cells with nutrients, a more sophisticated model is to grow cells in an air liquid interface with the top surface of cells exposed to air and the bottom to the liquid with nutrition.  This more closely mimics the real life situation.  When cells are studied in air liquid interface it is very important to make sure they are not damaged by the experiment un

Chemical Genomic Analysis of the Mode of Action of Novel Boron-Containing Antifungal Agents for Crop Protection

Fungal pathogens of agriculturally significant crops pose a serious threat against global food security. This is exacerbated by the limited classes of fungicides that are commercially available for the farmers and the rapid emergence of resistance against the existing fungicides. Furthermore, resistance against agricultural fungicides can poses serious threat to human health as it can provide cross-resistance to the antifungal drugs that are used in the clinics world-wide.