Peptides control a vast range of intra- and intercellular processes. However, linear peptides suffer from instability and poor cell permeability, which limits their application as therapeutic agents. In contrast to linear peptides, cyclic variants are more resistant to both exo- and endoproteases, which explains the therapeutic potential of this class of molecules. Peptide macrocycles have shown remarkable capacity for functional fine-tuning.
New technologies are needed to meet the environmental targets set for the future of air and ground transportation, and to reduce dependence on fossil fuels for electric power generation. The present project aims at developing a novel flow control technology, which can generate significant aerodynamic improvements, leading to reduction of aerodynamic drag of air and ground vehicles, and better efficiency and durability of wind turbines.
The goal of the project is to further develop the Fork Configuration Damper – FCD (patents pending in 7 countries) to enable its implementation in real structures and its commercialization through a University of Toronto startup company. The FCD is a new damping technology developed at the University of Toronto to mitigate wind and earthquake vibrations of high-rise buildings by increasing the level of distributed viscous damping in the structure. The FCD is embedded within structural configurations that are commonly used for high-rise buildings.
This proposal describes a research project towards a spoken dialog translation system that holds a broad range of potential applications. In particular, the proposal describes a system that will be developed and can be integrated in hand-held devices where a user may talk to the system in ones preferred language and the system produces a spoken translation of what is said in another language (e.g. Japanese to English or vice versa). The language barrier between any two dialog partners speaking different languages can be bridged with the help of such a system.
In general, if a user is not willing/able to implement himself the solution, attaching sensor and actuator equipment to a computer typically leads to disproportionately expensive purchases of proprietary hardware or software, which often still requires a considerable time investment. The goal of our planned company is to provide affordable computer-attached electronic equipment to individuals and businesses worldwide. Our devices will: (1) perform data acquisition and control of external hardware, i.e. input/output (I/O) operations; or (2) speed-up compute-intensive calculations.
The ever growing market demands for higher data rates and more reliable communication are the main drivers behind the technological growth in the wireless telecommunications industry. This R&D project aims to address an innovative technological shift from conventional wireless cellular networks to a paradigm of cooperative cellular networks that can potentially provide multiple-fold improvements in terms of the total data rates.
The main challenges in bioconversion of lignocellulose arise from our limited understanding of the heterogeneous chemistry of the substrate and poor accessibility of enzymes within dense wood cell walls. It is clear that our limited appreciation of enzyme penetration into cell walls and catalysis dynamics is partly due to the constraints of the techniques employed previously. Unlike these other studies, which addressed such questions by examining model substrates, I propose to examine and develop new tools for use on complex solid wood substrates.
The Toronto and Region Area of Concern (TRAOC) has been one of the most polluted sites in the Great Lakes posing health risks to millions of people. The Remedial Action Plan (RAP) has made significant progress towards restoring the system and meeting the delisting targets. Yet, several critical questions still need to be addressed, such as: How close is the Toronto ecosystem currently to meeting the TRAOC RAP delisting criteria? What additional research and assessment will be required to guide remedial actions? Which attributes best reflect the integrity and health of the ecosystem?
One of the proposed benefits of adopting electronic health records is the development of a comprehensive database which can be used for epidemiological, clinical, and health services research. The main purpose of this project is to develop strategies and provide case examples of how data from these extensive electronic databases can be used to improve healthcare services outcomes. TELUS Health Solutions’ Oacis (i.e., Open Architecture Clinical Information System) has been in use in a large health care organization for approximately 15 years.
Pulse shaping devices are the key elements for optical signal processing that are capable of reshaping the temporal waveform of optical pulses. The applications of pulse shaping devices include ultrahigh-speed optical telecommunication, ultrafast all-optical computing and information processing, biomedical imaging, and electronic and photonic signal/device characterization and monitoring. For these applications, ultrafast optical waveform shapers capable of synthesizing temporal waveform features down to the sub-picosecond regime are required.