Effets biologiques de synergies d’extraits naturels sur l'anxiété et certaines conditions inflammatoires en relation avec l'axe microbiome-endocannabinoïdome

Mon projet de maîtrise vise à développer des produits de santé naturels à base d’extraits naturels, non issus du cannabis, qui ont des effets bénéfiques sur la santé, plus précisément de prévenir l’inflammation et l’anxiété. Plus spécifiquement, il a pour but de démontrer que la modulation du système endocannabinoïdome par certains extraits naturels entraîne des effets positifs sur la santé. L’objectif final est de concevoir des suppléments alimentaires vendus sous forme de capsules.

Un des composés étudiés est riche en ADP, un omega-3 qui est rare.

Development of a Proof of Concept for a System to Increase Success Rates of Organ Transplant and Donation Matches

Transplantation is the preferred treatment for patients whose kidneys have failed. There is an ever-growing gap between patients in need for a transplant and available donors. In response to this need, there has been an increase transplantation of donors who experienced circulatory determined death (DCD). However, many potential DCD donors fail to end up in transplantation.

Design and Deploy PI-Containers on Pharma (Vaccine& Repurposing Inhibitors) Supply Chain based on Physical Internet and Blockchain Technologies

The excellent work expected by the intern will contribute to R&D McGili Canada significantly, especially her expertise and research experience in pharma industry; Physical Internet is an open innovation ecosystem, the innovation avenue and business potential will be demonstrated based on the stage-based collaborative efforts.

Briser l’isolement des ainés en temps de COVID-19 grâce au système d’échange local mis en place par l’Accorderie de Sherbrooke

L’urgence sanitaire liée à la COVID-19 a forcé les ainés à adopter des mesures drastiques de confinement qui les mettent à risque d’un isolement. À long terme, ce confinement peut conduire à un désintérêt de la vie. L’organisme communautaire l’Accorderie de Sherbrooke, qui propose un système d’échange local entre ses membres, a mis sur pied dès le début du confinement un programme de jumelage entre un membre et un ainé pour les livraisons à domicile, générant 120 nouveaux membres.

Modelling Acute Respiratory Distress Syndrome (ARDS) in Precision Cut Lung Slices

With the support of Mitacs, Dr.Ynuk Bossé’s laboratory and SCIREQ will collaborate to refine the techniques and instrumentation needed to improve Precision-Cut Lung Slices (PCLS) studies. PCLS are thin organ slices prepared from fully developed organs. They represent a “mini-model” that closely resembles the whole lung in both anatomical structure and rich cellular environment. Dr.Bossé and SCIREQ’s joint efforts will help scientists better understand and treat lung diseases, such as the Acute Respiratory Distress Syndrome (ARDS) in the context of COVID-19.

Efficacy and mechanism of action of CB1R inverse agonists for enhancing insulin secretion and for preventing metabolic stress and cytokine-induced ?-cell death in human islets

Inversago and the Prentki Laboratory at CR-CHUM will collaborate to evaluate new generation Cannabinoid-1 receptor (CB1) blockers for the treatment and/or prevention of type-1 and type-2 diabetes. Previous generations of CB1 blockers have shown their promise in treating several features of the metabolic syndrome, including obesity, type-2 diabetes and liver diseases. However, they were plagued with important psychiatric adverse effects which eventually caused the termination of all development and commercial efforts.

Does multimodal prehabilitation reduce cardiovascular complications in high-risk surgical patients? A pilot randomized controlled trial.

Cardiovascular complications after major surgery, such as death, heart attack and stroke, contribute significantly to perioperative morbidity and mortality. Patients at high-risk of complications after surgery can be accurately identified by measuring brain-natriuretic peptide (BNP) in the blood, however limited interventions exist to reduce their risk of complications and improve their recovery. Prehabilitation is an emerging concept that aims to optimise a patient’s physical, nutritional, and mental health prior to major surgery in order to improve postoperative recovery.

Development of novel protease inhibitors active against the SARS-CoV-2 coronavirus

Effective anti-viral therapies are required to treat individuals infected by the SARS-Cov-2 virus, the causative agent of COVID-19. So far, only repurposed drugs have been investigated as treatment to fight SARS-Cov-2 infection. The goal of the project is to use our custom yeast-based screening platform in collaboration with the artificial intelligence algorithms of InVivo AI to develop specific inhibitor of SARS-CoV-2 enzymes called proteases.

Santé et bien-être des veaux laitiers de la ferme laitière à l’engraissement

Les veaux mâles issus des fermes laitières sont généralement transportés vers les encans en jeune âge où ils sont vendus puis transportés vers les fermes de veaux lourds du Québec (veaux de lait ou de grain). La santé et les caractéristiques zootechniques de ces jeunes veaux sont un enjeu majeur pour le bien-être animal et afin de limiter les problèmes associés aux maladies (utilisation des antibiotiques, risque de mortalité).

Implication of the nucleotide pool sanitizing enzyme NUDT1 in vascular remodeling in pulmonary arterial hypertension (PAH)

Pulmonary arterial hypertension (PAH) is a progressive condition characterized by the chronic elevation of pulmonary artery (PA) pressure leading to failure of the heart. In spite of recent advances in approved therapies, PAH remains a serious disease with significant mortality.

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