Increasing the expression of frataxin with the CRISPR system

Friedreich is an hereditary disease, which in due to a mutation of the frataxin gene. This mutation leads to a reduced production of the frataxin protein. This leads to oxidative stress and death of the cells. The death of the neurons and cardiomyocytes are responsible for progressive severe neurological and cardiac symptoms.

Sensors Western Operational Research and Development (SWORD)

Accurate monitoring of a patient’s vital signs – including body temperature, blood pressure, and pulse oxygenation – is central to the ability of clinicians to provide appropriate medical care. In spite of this, the standard equipment used to take these measurements is inefficient, inconvenient, and expensive. Adept Diagnostics will break into the medical device market with the development of novel wireless sensor systems to track these physiological variables continuously and inobtrusively.

Synergistic actions of nutraceuticals on pain and inflammation in experimental arthritis

Arthritis is among the most common chronic conditions in Canada in both children and adults. Arthritis is a potentially disabling disease causing joint inflammation and pain. Increasingly, people suffering from arthritis are using alternative therapies including nutraceuticals. This research aims to create new knowledge about the synergistic effects of gamma-linoleic acid (GLA), eicosapentanoic acid (EPA) and docosahexanoic acid (DHA) with and without boswellia serrate extract to improve pain and inflammation in models of juvenile and adult arthritis.

Computer aided system based on Image processing technique for assessment ofspinal cord from MRI Year One

The spinal cord is one of the most important neurological structures in the body. Noninvasive image-based assessment of this structure is an increasingly demanding healthcare service. This project is a preliminary development stage of a computer-aided spinal-scan assessment software toolkit which aims at faciiitating the diagnosis of spinal cord problems. In parlicular, the proposed project is to design computational methods which automatically extract image fearures.

Radiochemistry for the Pharmacokinetic Evaluation of Novel Bone-Targeting Peptide Hormone Derivatives Year Two

This proposed research project is about development of new bone-targeting drug called PTHPEG- BP, this new compound will overcome shortages of current clinical peptide hormone PTH, and show better treatment efficacy and lower price then the latter; several new technologies will be used on research of this PTH, such as micro Positron Emission Tomography (PET/CT), and several of its characteristics will be identified such as structure, bioactivity, and metabolism inside body.

Isolation, characterization and culture maintenance of stem cells from human hair follicle mesenchyme Year Two

Stem cells and other pluripotent cells are under active investigation for the development of new therapeutic treatments to regenerate and repair diseased and damaged tissues. Published studies indicate that some mesenchymal cells derived from adult human hair follicles exhibit stem cell properties and can form different cells types if they are given specific biological signals without the need to genetically modify the cells.

Development of Radio-Imaging Agents Targeting Necroptosis Year Two

The joint-effort project by Nordion Inc and the University of Ottawa Heart Institute aims to develop a series of radiolabeled necrostatin derivatives, which act as imaging agents based on necroptosis (programmed necrosis - a type of cell death) inhibitors to help diagnose disease (such as cardiovascular, neurological diseases and cancer) and monitor their treatment effects. The roles of the fellow are to design, synthesize and characterize these agents and to assist in testing their biological properties through further in vitro and in vivo evaluation.

Development of Fast Longitudinal Cortical surface extraction, deformation, and Normalization (FALCON) for the measurement of cortical thickness over time from brain magnetic resonance images Year Two

The project involves development, validation, and application of new medical image analysis algorithm where cortical thickness is measured from serial brain magnetic resonance imaging (MRI) with improved efficiency and greater sensitivity. Cortical thickness is a relatively new metric that correlates with clinical and cognitive worsening in a variety of neurologic disorders such as multiple sclerosis and Alzheimer's disease.

Postnatal development in mice and rabbits: an histomorphological study

his study focuses on the postnatal histomorphology of developing organs in mice and rabbits and compares the key events between human and experimental species (mice and rabbits). It will provide an essential resource for nonclinical safety evaluations of pediatric drugs and will be helpful in preparing appropriate study designs and testing strategies. Neonatal and juvenile organs greatly differ morphologically and functionnally from adult animals.

The evaluation of pain management strategies for either caustic paste or cautery disbudding in dairy calves Year Two

Destruction of the horn bud in 4-6 wk old calves using either hot-iron or chemical disbudding is a common practice in the dairy industry. There is a limited body of research on the effects of chemical disbudding and the pain it causes to the animal as well as research on appropriate methods to mitigate the pain following this procedure, and research to identify appropriate pain managements is needed.