Tumor Reduction and Enhanced Responsiveness to Radiation Therapy and Chemotherapy Via Selective Removal of Iron: Mechanism and Preclinical Evaluation

Objectives: The objectives of this study are to use in vitro and in vivo models to validate the hypothesis that the ironchelator, DIBI, can selectively inhibit the proliferation and survival of breast cancer cells and that the combination of this chelator with radiation or standard chemotherapeutic agents (e.g., cisplatin and docetaxel) increases the sensitivity of breast cancer cells to the treatment regime. In collaboration with Chelation Partners Inc.

Development of 3D culture reagents and scoring systems for assays of normal andmalignant epithelial stem cells

The overarching objective of this proposal is to develop and validate a new, robust and reproducible 3D culture system that supports the clonal growth of primary sources of normal and malignant human epithelial cells and that is suitable for commercialization by STEMCELL Technologies who will partner in its development. The work will systematically address 3 Specific Aims.

Predictive microsimulation model for knee-OA progression and cost-effectiveness of earlynon-pharmacological therapies to improve long term patient outcomes

The proposed study has three objectives:

Objective 1. Develop KOA microsimulation model: To develop and validate a Knee-OA population-based microsimulation model (POHEM-KOA) using the previously developed POHEM-OA model.

Objective 2. Perform cost-effectiveness analysis of non-pharmacological therapies for KOA: To use POHEM-KOA in conducting a cost-effectiveness analysis of treatment strategies, including exercise therapy and weight reduction, targeted at obese and overweight early OA patients in Canada over the next 20 years [2013, 2033].

ENGAGE: The Role of Academic Research and Technology Innovation for Improving Parkinson’s Disease Outcome and Life-style modifications

Phase I: Development of Intellectual Property to Facilitate Partnership Agreements with Business and Non-profit

Organization

Computer Aided Spinal Cord-MRI Assessment System basedon Digital Image Processing Techniques

The spinal cord is a main pathway connecting the brain to the peripheral nervous system. Noninvasive image?based assessment of this structure is an increasingly demanding healthcare service. This project cultivates the engineering techniques required for the development of a computer?aided spinal?scan assessment software toolkit for diagnosis of spinal cord problems.

The evaluation of pain management strategies for either caustic paste or cautery disbudding in dairy calves

Destruction of the horn bud in 4-6 wk old calves using either hot-iron or chemical disbudding is a common practice in the dairy industry. There is a limited body of research on the effects of chemical disbudding and the pain it causes to the animal as well as research on appropriate methods to mitigate the pain following this procedure, and research to identify appropriate pain managements is needed.

Technologies for Living Independently: A Technology Case Study on Remote Patient Monitoring

The population age distribution is undergoing an “inversion” and the dependency ratio, i.e., the proportion of older adults who are not working over the number of adults who are working, is increasing. This has an effect on a society’s ability to deliver community-care services and the underlying national economic capacity to pay for their needs. Advances in ICT (information and communications technologies) promise to provide support for affordable systems of care that enable human resources to be used more effectively.

Development of Fast Longitudinal Cortical surface extraction, deformation, and Normalization (FALCON) for the measurement of cortical thickness over time from brain magnetic resonance images

The project involves development, validation, and application of new medical image analysis algorithm where cortical thickness is measured from serial brain magnetic resonance imaging (MRI) with improved efficiency and greater sensitivity. Cortical thickness is a relatively new metric that correlates with clinical and cognitive worsening in a variety of neurologic disorders such as multiple sclerosis and Alzheimer's disease.

Development of Radio-Imaging Agents Targeting Necroptosis

The joint-effort project by Nordion Inc and the University of Ottawa Heart Institute aims to develop a series of radiolabeled necrostatin derivatives, which act as imaging agents based on necroptosis (programmed necrosis - a type of cell death) inhibitors to help diagnose disease (such as cardiovascular, neurological diseases and cancer) and monitor their treatment effects. The roles of the fellow are to design, synthesize and characterize these agents and to assist in testing their biological properties through further in vitro and in vivo evaluation.

Isolation, characterization and culture maintenance of stem cells from human hair follicle mesenchyme

Stem cells and other pluripotent cells are under active investigation for the development of new therapeutic treatments to regenerate and repair diseased and damaged tissues. Published studies indicate that some mesenchymal cells derived from adult human hair follicles exhibit stem cell properties and can form different cells types if they are given specific biological signals without the need to genetically modify the cells.

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