Detection and prevention of preeclampsia using metabolomics and Vaccinium leaf extract for human trophoblast survival

Blueberry leaves are gynaecological aids and inhibitors of advanced glycation endproducts (AGEs). AGEs cause atherosclerosis, kidney, vascular, and neurological diseases through an oxidative process and correlate with preeclampsia. Preeclampsia affects 2-7% of women and is a leading cause of maternal/perinatal mortality. A woman dies of preeclampsia every eight minutes worldwide. Unfortunately, randomized trials evaluating dietary, vitamin, mineral treatments showed minimal benefit in reducing preeclampsia. AGEs are associated with preeclampsia.

Evaluating New Methods for Monitoring Cognitive Health Year Two

Copeman Healthcare Centre is engaged in a multi-year research and development program in the area of cognitive health. Cognitive health is a surrogate marker for brain health. All other technologies, such as biomarkers, electrophysiology, structural brain imaging, and functional brain imaging attempt to measure damage to the brain. Moreover, these technologies do not measure or quantify the healthy brain or its functioning; they are used to detect what appears to be wrong based on anatomical or physiological indicators.

Evaluating New Methods for Monitoring Cognitive Health

Copeman Healthcare Centre is engaged in a multi-year research and development program in the area of cognitive health. Cognitive health is a surrogate marker for brain health. All other technologies, such as biomarkers, electrophysiology, structural brain imaging, and functional brain imaging attempt to measure damage to the brain. Moreover, these technologies do not measure or quantify the healthy brain or its functioning; they are used to detect what appears to be wrong based on anatomical or physiological indicators.

Guided Catheter System Based on Smart Polymeric Brush Coating for Vascular Surgery Year Two

Ventures (IV)~ Canada supports the development of novel application for guided catheters and serving the CVD market, it will directly benefit from this research. We anticipate generating new intellectual properties based on the work described. N previously licensed a technology from the research performed in Kizhakkedathu and Phani's laboratories on catheters and the current project will expand that technology further.

Guided Catheter System Based on Smart Polymeric Brush Coating for Vascular Surgery

The main cause of cardiovascular disease (CVD) is narrowing of blood vessels due to atherosclerosis. In such cases stents are chronically implanted in -arteries to physically expand and scaffold the vessels. Each year, ~90,OOO stents are implanted in Canadians. All these minimally invasive procedures involve the use of a catheter. Currently available catheter tubes advance straight in blood vessels; it remain a challenge to the cardiac catheterization in bifurcated cardiac arteries which are blocked.

Radiochemistry for the Pharmacokinetic Evaluation of Novel Bone-Targeting Peptide Hormone Derivatives

This proposed research project is about development of new bone-targeting drug called PTHPEG- BP, this new compound will overcome shortages of current clinical peptide hormone PTH, and show better treatment efficacy and lower price then the latter; several new technologies will be used on research of this PTH, such as micro Positron Emission Tomography (PET/CT), and several of its characteristics will be identified such as structure, bioactivity, and metabolism inside body.

Next-generation preclinical development andassessment of engraftment efficiency of Sernova’s Cell Pouch System™ in clinical islet transplantation

This fellowship will develop next generation Cell Pouch™ technology, through testing novel animal study (anti-cell death agents, insulin-producing mouse stem cells and islet health (metabolic engraftment efficiency) in parallel to a safety and efficacy (Phase I/II) clinical study of the Cell Pouch™ in Type 1 diabetic in which an in vitro measure of islet health will be correlated to in vivo graft function.

"Indanio Fellowship Year Two *Renewal, previous title ""Indanio Fellowship"""

The proposed project goals are five fold:

1) Generate and lead initiatives in drug discovery especially in the area of target identification/validation.

2) Generate transgenic zebrafish lines for nuclear receptor diseases related to oncology and metabolic diseases

3) Apply and supervise drug discovery on nuclear receptor ligand trap fish lines in the area of metabolic disease / cancer to extend state of the art research that leads to the discovery of new therapies

Development of 3D culture reagents and scoring systems for assays of normal andmalignant epithelial stem cells Year Two

The overarching objective of this proposal is to develop and validate a new, robust and reproducible 3D culture system that supports the clonal growth of primary sources of normal and malignant human epithelial cells and that is suitable for commercialization by STEMCELL Technologies who will partner in its development. The work will systematically address 3 Specific Aims.

Phase I: Using simultaneous EEG-fMRI to study theaffective mechanisms underlying obsessivecompulsivedisorder

The aim of this project is to improve simultaneous EEG-fMRI techniques through the use of constrained principal component analysis (CPCA). The main problem with combining EEG measures and fMRI measures is that recording EEG in the MR scanner always injects noise into the data. CPCA partitions the variability of the data into systematic and error variance.

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