Prostate cancer (PCa) is the most common cancer affecting Western men. Unfortunately, treatment for advanced prostate cancer is strictly palliative and lethal treatment-resistant disease eventually arises (castrate-resistant prostate cancer (CRPC)). Interrogating the genome of pre and post CRPC allows for the identification genetic differences that drive progression and resistance, representing candidate therapeutic targets and molecular biomarkers.
A cochlear implant (CI) is a complex electronic device designed to provide the sensation of sound to profoundly deaf or severely hard-of-hearing individuals. Imaging of the implanted CI electrode would assist manufacturers in verifying the efficacy of their designs and would also provide important information to clinics for programming CIs post-surgery. However, the size and position of the cochlea in the body make it difficult to image using clinical imaging scanners.
Bleeding following traumatic injury is the leading cause of early cause of death. Currently these patients are treated based on the results of time consuming laboratory tests resulting in inappropriate usage of blood products and poor survival rates. Rapid recognition of defects in clotting mechanism is necessary to stop bleeding in trauma patients.
Les études démontrent que 15-20 % des patients sont insatisfaits en post prothèse totale du genou. Plusieurs de ces patients présentent de la douleur antérieure. Dans le cas du syndrome fémoro-patellaire, différents déficits biomécaniques pouvant expliquer ces symptômes ont été identifiés. Cependant, aucune étude ne s’est intéressée à la biomécanique du genou chez une population souffrant de douleur post prothèse.
Oocyte cryopreservation is imperative for assisted reproductive technologies (ART). It offers cancer patients to preserve their oocytes for future fertilization, flexibility in the timing of infertility treatment, and the potential for establishing oocyte banking. However, the currently available protocol is limited because the oocytes after cryopreservation have lower ability to develop into viable embryos (developmental competence) compared to unfrozen oocytes.
The incidence of female infertility is on the rise in Canada, afflicting up to 17% of woman between the ages of 18 to 34 and with a considerably higher rate of occurrence in woman over 34. Many infertile women are now turning to assisted reproductive technologies (ART) to facilitate conception and child bearing. Female oocyte/egg competence is an important requirement for successful ART outcomes. A competent oocyte is characterized by its ability to mature, become fertilized, and develop into a viable embryo.
Osteoarthritis is a chronic painful disease of joints that involves the progressive destruction of the articular cartilage and bone and leads to pain. It affects both humans and animals. Animals can serve as models for the human disease and in this case we will study equine OA. There is currently no effective medication that can effectively reverse the cartilage destruction in OA. This is mediated by enzymes. It was believed to be due to MMP enzymes alone until recently we showed that Cathepsin K is also involved.
With the advances of medical imaging, accurate diagnosis has been significantly enhanced, especially when utilizing cross-modality imaging for complicated diagnoses such as the spine and cardiovascular system. However, cross modality image processing poses a challenge due to large amount of data generated. Computer Tomography (CT) and Magnetic Resonance Imaging (MRI) images, for example, have great capacity for screening, diagnosis, treatment and prevention of cardiac and spinal diseases.
Post-operative insulin resistance, hyperglycemia and loss of body protein are the features of post operative stress- induced catabolic response which is associated with increased morbidity, mortality and adverse outcomes post operatively. There has been a great deal of research on different approaches to optimize the post-operative insulin sensitivity such as hormonal and nutritional modifications and interventions, developing minimally invasive surgical techniques and epidural anesthesia. However, the correlation between insulin resistance and body protein loss is not well understood.
According to Statistics Canada 2012, Arthritis is one of the most common chronic conditions affecting 4.4 million Canadians and 101.504 people in Newfoundland. It is also the most common cause of disability between the ages of 40 and 70 years. People with chronic arthritis have several numbers of other coexisting conditions such as high blood pressure, heart diseases, obesity. Precancerous lesions and cancer are a significant part of these coexisting conditions. Many reports suggest that inflammatory arthritis is associated with an increased prevalence of malignancies.