Electrophysiological studies of medical cannabinoids on 3D human cerebral organoids and neuroglial cultures

Epilepsy, characterized by recurrent seizures, affects 1% of the population. More than 30% of patients are drug-resistant, a significant burden to their lives. New innovative ways to treat the disorder are needed. Cannabidiol (CBD), a nonpsychoactive compound derived from the cannabis plant, has been shown to be a promising new treatment for epilepsy. In collaboration with Avicanna, we will test the antiepileptic effects of CBD and other cannabinoids alone and in combination with common anticonvulsant drugs on both mouse and human brain tissue. In addition, we will also develop a high-throughput multi-well brain slice recording system.

Faculty Supervisor:

Peter Carlen


Yasaman Javadzadeh;Alexandra Santos


Avicanna Inc


Engineering - biomedical


Professional, scientific and technical services


University of Toronto



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