Fabrication of Antifouling Liquid-Infused Catheters

Catheter-associated infections (CAIs) pose a significant healthcare challenge in Canada and worldwide. CAIs contribute to increased patient morbidity, prolonged hospital stays, and a significant burden on the healthcare system. With an aging population and growing antimicrobial resistance, there is an urgent need for innovative infection prevention strategies.

This project explores using repellent liquid-infused catheters to reduce bacterial adhesion and biofilm formation, a significant complication with CAIs. Inspired by nature’s self-cleaning surfaces, these catheters utilize a tethered lubricant layer to create a dynamic, repellent interface, aiming to prevent bacterial colonization and subsequent biofilm formation. This project will explore scalable manufacturing processes to produce micro/nano-topographies on the surface of medical catheters to enhance the stability of the liquid-infused layer. Unlike conventional antibacterial coatings, this protective strategy does not rely on antibacterial agents, reducing the risk of developing resistant superbugs.

Through laboratory testing, we aim to evaluate the effectiveness of the developed catheters in reducing bacterial attachment and transmission. Furthermore, scaleup manufacturing and commercialization of these catheters will be explored in collaboration with FendX Technologies Inc. This research aligns with Canada’s commitment to healthcare innovation and infection control, ultimately improving patient outcomes and reducing the burden CAIs pose on the healthcare system.

Faculty Supervisor:

Tohid Didar

Student:

Partner:

FendX Technologies Inc.

Discipline:

Engineering

Sector:

Manufacturing; Professional, scientific and technical services

University:

McMaster University

Program: