In-vitro evaluation of hypervalent antimicrobial agents on epidermal cell susceptibility, proliferation, and migration

Inorganic elements, such as silver and copper, have long been used as effective antimicrobial and antifungal agents. Although the introduction of antibiotics in the early 20th century diminished the use of inorganic antimicrobials, increasing incidence and prevalence of antibiotic resistance has led to a resurgence of interest in alternative antimicrobial technologies. However, valid concern over the potential toxicity of inorganic antimicrobial that have resulted in skepticism and limited clinical adoption. Drawing upon the positive outcome of higher oxidation state silver to combat resistant organisms, here we evaluate the impact of these active ingredients on wound healing factors including cell migration, differentiation, and inflammation. Working with a multidisciplinary team, the outcomes from this study will translate directly from bench to bedside ensuring the development of novel medical devices to, not only combat antimicrobial resistance, but facilitate wound healing and benefit patient safety.

Faculty Supervisor:

Katalin Szaszi

Student:

Partner:

Exciton Technologies Inc (ON)

Discipline:

Life Sciences

Sector:

Manufacturing; Professional, scientific and technical services

University:

University of Toronto

Program: