Multi-Gram Scale Synthesis, Purification and Formulation of Psilocybin

Mental illness and addiction refer to a wide range of disorders that affects mood, behavior and thinking and thus leads to depression, anxiety disorders, substance use disorder and stress. The psychedelic drug assisted therapy functions as a mental health therapy, which is evolving at a quicker pace nowadays. These drugs are useful in the treatment of anxiety, depression, post-traumatic stress, obsessive-compulsive disorder, substance addiction, cancer-related and end of life anxieties. So, many researchers believe that these drugs if administered properly, could revolutionize mental health care, without having adverse effects. We plan to synthesize a very promising psychoactive drug psilocybin in multi-gram scale with high purity and will prepare its various formulation to manage its accurate amount of administration and controlled slow release. It will be further evaluated for its biological activity in collaboration of Halucenex life sciences, Inc. Over the period of 8 months, psilocybin will be synthesized, purified, characterized and formulated at Acadia University and bio evaluated at Halucenex life sciences Inc.

Faculty Supervisor:

Amitabh Jha

Student:

Smriti Srivastava

Partner:

Halucenex Life Sciences Inc.

Discipline:

Chemistry

Sector:

Professional, scientific and technical services

University:

Acadia University