Photoredox Fluorination: Selectively Synthesize 2-fluoro-2-methyl-2-deoxyarabinolactone Derivatives via a Radical Pathway

Natures ability to convert solar energy to chemical energy in photosynthesis has inspired the development of a host of photoredox systems in efforts to mimic this process. The capacity of fluorine atoms to engender a variety of useful properties in pharmaceuticals, agrochemicals, and performance materials has driven significant research efforts toward the invention of novel fluorination reactions. We
proposed to construct C-F bonds by photoreodox catalysis via a radical pathway. Our project will bring potential benefit to academia and industry. (1) Due to the novelty of the proposed idea using photoredox catalysts in C-H functionalization, it will be a highly efficient process to construct C-F bonds and applicable to a broad range of academic fields. (2) 2-fluoro-2-methyl-2-deoxyarabinolactone derivatives were selectively synthesized, which has many intrinsic advantages such as higher atom economy, cheaper starting materials, easier manipulation and more environmentally benign. Undoubtedly, this project will be of considerable interest for chemical industry and other related fields

Faculty Supervisor:

Frederick West

Student:

Zhenhua Jia

Partner:

TC Scientific Inc.

Discipline:

Chemistry

Sector:

Pharmaceuticals

University:

University of Alberta