Strontium loaded 3D printed scaffolds for improved bone regeneration

Strong evidence exists indicating the therapeutic potential of strontium in bone health and regeneration, and
perhaps treating metastatic bone disease. Since current standard treatments of large bone defects can still result
in poor outcomes (whether using autografts, allografts, ceramic or acrylic cements). New technologies and
advances in 3D printing with ceramics and other blended bioactive elements like strontium, may provide a new
pathway to improved treatments. There are several stable isotopes of strontium, and here we will test the impact
of scaffolds loaded with strontium on osteoblast and HUVEC adhesion, growth, viability and matrix deposition/tube
formation. Furthermore, we will apply scaffolds to a bone like microenvironment model representing a human 3D
bone-like tissue

Faculty Supervisor:

Derek Rosenzweig;Lisbet Haglund;Rahul Gawri

Student:

Partner:

Canadian Nuclear Laboratories

Discipline:

Life Sciences

Sector:

Professional, scientific and technical services; Public administration; Utilities

University:

Research Institute of the McGill University Health Centre

Program: