Using dermal stem cells for cartilage regeneration

Osteoarthritis (OA) is the fastest growing global health problem; with a total joint replacement being the only effective treatment for patients with advanced OA. While many studies have employed mesenchymal stem cells (MSCs) to repair cartilage; only little improvement has been observed and these MSCs are typically isolated from bone marrow or fat which requires invasive procedures. There is a growing body of literature demonstrating the MSCs derived from the dermis retain the ability to become cartilage, yet it remains unknown if these cells can affect cartilage repair. Thus, we will undertake a project with Acorn Biolabs to examine if their human dermal MSCs have therapeutic potential for cartilage injury and/or OA. These easy to obtain cells may provide a real option for the non-surgical management of this all too prevalent disease.

Faculty Supervisor:

Roman Krawetz

Student:

Partner:

Acorn Biolabs

Discipline:

Life Sciences

Sector:

Professional, scientific and technical services

University:

University of Calgary

Program: