Automated CNC processing of complex and high-aspect-ratio microfluidic devices for biomedical applications

Disposable microfluidic devices, also known as labs-on-a-chip, made out of plastic materials have seen increasing applications in chemical and biomedical analysis. In most applications, microfluidic devices usually incorporate small channels and chambers for micro sized dimensions, using heights between a few hundred to a few micrometers. Currently, manufacturing processes have been established to create these […]

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Multi-user Training Software Development and Otoscope Tracking for Otolaryngology Education

Simulation is being used increasingly to improve medical education by providing students and trainees with greater access and opportunity to learn critical skills without affecting actual patient care. To this end, OtoSim has developed a multi-user training platform and an otoscope tracking device. The multi-user training platform allows the trainee to self-learn while being electronically […]

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Self-powered microchips for rapid diagnosis and severity determination of urinary tract infections

Children presenting a fever without known sources are usually checked for bacterial urinary tract infection (UTI) which, in its more complicated forms, can result in permanent kidney damage. The gold standard conventional tests to diagnose complicated urinary tract infections are urine culture and kidney imaging with a radioactive tracer. However, these tests are lengthy (urine […]

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Development of Smart Socks To Prevent Diabetic Foot Ulcers

Diabetic patients suffer from reduced sensation in their foot which will be leading to foot ulcers that are hard to treat, and often resulting in limb amputation. The existing health-care techniques usually fail to prevent foot ulcers because they cannot monitor the foot in real-time. In this work, we seek to develop smart socks based […]

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Development and Validation of Software for the Three-dimensional Quantification and Visualization of Blood Flow Hemodynamics in Patients with Aortic Insufficiency using 4D flow MRI. Year 2

The aim of this proposal is to assist in the development and validation of a dedicated 4D flow MRI analysis software for the evaluation of aortic valve insufficiency. Before being commercialized this software requires validation considering the large amount of data required to be pre-processed (over 2,000 files per case), elemental data corrections, data analysis […]

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Development of a simulation model for prediction of performance of a novel positive airway pressure (PAP) machine for treatment of sleep apnea

The gold standard of treatment for patients with sleep apnea are Positive-airway-pressure (PAP) machines. PAPs provide a one-size-fits-all solution of providing the same therapy in terms of airflow to every patient and every breath. This causes frustration and discomfort for patients, therefore patients don’t purchase PAPs or purchase and don’t use them; leading to 4 […]

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Improving Signal Prediction of a Real-time Radiotherapy Beam Monitor using Artificial Neural Network

The science and technology of Radiotherapy for treating cancerous tumor more accurately and precisely is improving constantly with the availability of cutting-edge imaging systems in Radiation Treatment room, and advancements in computer technologies. However, these improvements are associated with complexities and potential risks. To mitigate the risks, a new class of Quality Assurance (QA) systems […]

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Using multivariate deep-learning algorithms for automatic quality control of high-resolution MRI – Year two

NeuroRx is an imaging contract research organization (CRO) specialized in the central nervous system (CNS) that utilizes state-of-the-art digital image processing techniques to produce accurate and precise outcome measures for clinical trials of drugs in development. Prior to analysis, all scans must pass Quality Control (QC). The goal of this project will be to incorporate […]

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Robust Magnetic Resonance Imaging of Short T2 Tissues

Magnetic resonance imaging (MRI) is an imaging modality which can visualize the internal structure of the human body and is free of radiation. In this project, we would like to write a multi-functional and robust MRI software package using ultrashort echo time (UTE) technique to realize the imaging of the tissues, such as tendons, ligaments, […]

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Design of a Multi-modal Electronic Stethoscope for the Digital Acquisition and Automatic Diagnosis of Auscultation Signals

The proposed research project aims to develop a multi-modal stethoscope, containing superior digitized heart and lung sounds, telemedicine capabilities and assistive diagnostics. This is achieved by leveraging new advancements in piezo, microphone, wireless and machine learning technologies. The project will investigate these technologies and integrate them into custom made electronics and mechanical designs to achieve […]

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Application for bacteriophage encapsulation in biodegradable polymers for the prevention of prosthetic joint and suture infections

The aim of this project is therefore to develop polymer-based formulations of bacteriophages to combat microbial infections. Bacteriophages are a class of viruses specific to bacteria that are not subject to antibiotic resistance and are the most prevalent organisms of the human virome, and therefore safe.2 We will use different polymer compositions and blends to […]

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A Vision-based system for intelligent monitoring of gait poses in dementia

Impairments of gait and balance often progress through the course of dementia, and are associated with increased risk of falls. Regular assessment of gait and balance could therefore be informative in tracking changes in functional status, and identifying individuals at a high risk of falling to allow for preventative measures. We have developed a technology, […]

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