Carbonate Alteration Footprints of Hydrothermal Ore Deposits Year Two

Carbonate hosted hydrothermal ore deposits commonly develop narrow mineral alteration (i.e. visible) haloes, complicating exploration targeting. In contrast, hydrothermal modification of the country rock’s stable isotope composition usually extends far beyond visible alteration. Hence, stable isotope “mapping” is an effective tool to aid exploration for carbonate?hosted deposits. However, widespread utilization of stable isotope data has […]

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In vivo efficacy and safety of novel therapeutic host defense peptides

Biofilms are clusters of bacterial cells that grow together on a surface. Biofilms are often associated with infections (~65%) but they are exceedingly difficult to treat with conventional antibiotics and there are currently no biofilm-specific treatments available on the market. Some common biofilm-associated infections include skin and sinus infections as well as infections associated with […]

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Non-Viral delivery of insulin and IL-10 to the intestine for immunotherapy for type 1 diabetes Year Two

There is increasing evidence suggesting a link exists between the gut immune system and several autoimmune diseases, including diabetes. The industrial partner of this project, enGene, has developed an effective non-viral based technology for the delivery of genes to the intestine. enGene has demonstrated the feasibility of delivering IL-10, which is an anti-inflammatory cytokine, to […]

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Investigating the biophysics and structural basis for state dependent drug blockade of persistent/late sodium current (INa(P)) in the heart using photoactivatable crosslinking unnatural amino acidsYR2

Electrical activity in the heart is controlled by the concerted activity of many proteins called ion-channels that regulate the transfer of different ions across cell membranes. Recently, researchers in biomedical science have identified that a particular component of sodium carrying ion-channel activity (called the persistent or late sodium current also known as INa(P)) played a […]

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Isolation, characterization and culture maintenance of stem cells from human hair follicle mesenchyme Year Two

Stem cells and other pluripotent cells are under active investigation for the development of new therapeutic treatments to regenerate and repair diseased and damaged tissues. Published studies indicate that some mesenchymal cells derived from adult human hair follicles exhibit stem cell properties and can form different cells types if they are given specific biological signals […]

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Development of a bio-based non-isocyanate polyutherane

This project aims to innovate a Made-in-Canada methodology for producing non-isocyanate polyurethane (NIPU) to replace traditional polyurethane (PU) rigid foam which is produced through a hazardous process from toxic materials such as isocyanates and phosgene.1 We aim to partner with Polychem Consulting Solutions Ltd, a privately held Canadian company based in Vancouver, BC and a […]

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Indigenous Foodlands Conservation Areas

The Indigenous Foodlands Conservation Areas Project will conduct participatory action research with Elders, Indigenous knowledge holders and Indigenous law/governance experts to support the BC Working Group on Indigenous Food Sovereignty and the IISAK OLAM Foundation in the process of mapping out and advocating for Indigenous Foodland Conservation Areas in Neskonlith Secwepemc territory. In the Neskonlith […]

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The potential to produce lower carbon intensive (CI) transportation fuels via co-processing at existing oil refineries

Co-processing has been commercialised by Parkland Burnaby refinery which allows the refiner to produce lower carbon intensity fuels. Significant amount of process data has also been generated. The intern made use of the commercial data and evaluated the impact of these alternative feedstocks to existing refining operation, like yield, operating conditions. More importantly, the intern […]

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A methodology to leverage seismic risk assessments to inform seismic policy development in the City of Vancouver

Seismic risk reduction planning for existing buildings must begin with a quantitative account of risk, and it must contain an objective basis grounding the various policy options considered within it. This work aims to develop a methodology to generate that objective policy basis, leveraging seismic risk modelling outputs to detail the benefits of various policy […]

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Flow: A live captioning system for dysarthric speech

In recent years, video conferencing has become a popular communication channel. However, for people with Parkinson’s disease, speech problems like stutters, gaps, and ticks can quickly derail a conversation and render video communication services unusable. Live captioning can be very helpful, but only if the captions have sufficient quality. To facilitate communication, we propose to […]

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