Developing and implementing novel microfluidic scanning probes for spatial profiling of heterogenous tumor samples via a multi-omics approach

The aim of the project is to develop microfluidic technologies to analyse heterogenous tumor tissues/cells via a multi-modal approach using spatial genomic, transcriptomic and proteomic data. The resulting data obtained could be used for prognostics, diagnostics and prediction of therapies. Microfluidic scanning probes (MFP) technology, invented by the Kaigala team while at IBM Research in […]

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CADSIM Plus simulator, evolutionary algorithms, rule based expert system, neural network.

In industries, chemical processes involve different plants running in parallel with different production rates under the strict constraints on available resources. Therefore, events like shutdown of one or more plants, operating plants with different production grades with flexible run length time, equipment utilization rates of different plants etc. are vital to be studied, scheduled, and […]

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Designing and engineering scalable lipid-based drug delivery systems to improve the delivery and bioactivity of cannabinoids

It is clear that Cannabis has therapeutic activity. The evidence comes from a long history of use for managing disease symptoms including pain, inflammation and anxiety. However, there is a paucity of scientifically rigorous research exploring the specific activity of Cannabinoids in the body under both normal and disease states. With the legalization of Cannabis […]

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Conserved epitope locations and entry mechanisms in SARS-CoV-2 Spike protein and their applications to viral evolution and novel vaccine design

As the ongoing COVID-19 pandemic continues to affect people throughout the world, the inherent possibility of SARS- CoV-2 to mutate and evolve into further novel variants and strains of which considerable dangers and public health risks apply remains prevalent. As the world has already witnessed, these new variants carry the potential to be both more […]

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How much room for the river? Balancing societal and environmental targets in river management and restoration

River management aims to balance environmental needs such as habitat against the protection of infrastructure (e.g. roads, pipelines, property) from flooding, erosion, and other geohazards. The ability to effectively navigate this trade-off stems from a fundamental understanding of how rivers function. However, management projects often rely on highly simplified models of river processes (such as […]

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Point of care ultrasound in rural British Columbia: An investigation of quality and effect on clinical management decisions

Health care providers perform ultrasound exams to see a patient’s internal physiology (e.g., organs). Point of care ultrasound (PoCUS) refers to ultrasound exams performed at the bedside by a physician not specialized in imaging. PoCUS use by general practitioners is increasing, including in rural British Columbia (BC). Rural PoCUS has the potential to improve the […]

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Characterizing the relationship between aroma profiles and odour perception in northern highbush blueberries

Blueberries consumption has increased in the last decades due to their delicious flavour and recognized health benefits. However, even if the blueberry flavour is naturally delightful, some consumers are concerned because this flavour is not consistent over weeks, which could result in a decreased purchasing interest. Blueberry flavour depends on many factors, especially the genetic […]

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Development and validation of a risk prediction model for severe exacerbations in patients with severe asthma

Asthma is a common disease of airways affecting 339 million people worldwide. About 5-10% of asthma patients have severe asthma, which is associated with disproportionately high risk of exacerbations (‘lung attacks’) and death. It also contributes to nearly 50% of asthma-related healthcare spending. In particular, exacerbations are a major source of burden in severe asthma. […]

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Characterizing the wood construction waste stream in BC and evaluating the mechanical performance of new recycled products

Wood waste from Construction, Renovation and Demolition (CR&D) contributes about 7 % of the total waste sent to Canada’s municipal solid waste (MSW, or landfill) sites, according to a 2013 report from Natural Resources Canada (NRCan). This preliminary project aims to consider viable alternatives to utilize waste wood to manufacture engineered wood products for the […]

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