Organohalide-respiring bacteria (OHRB) are important agents of bioremediation, helping to clean up groundwater contaminated with toxic compounds such as chloroform, perchloroethene (PCE), and chlorobenzene. This metabolic pathway relies on enzymes known as reductive dehalogenase homologs (RdhAs). The mechanisms by which RdhAs reduce organohalides remains elusive, particularly in the case of the Chloroflexi OHRB Dehalococcoides and […]

Over 170 million persons worldwide are chronically infected by hepatitis C virus (HCV), leading to endstage liver disease and cancer. HCV is the single most common indication for liver transplantation in Canada and the rest of the Western world. After transplant, HCV re-infection is universal and is the chief cause of graft loss. Treatment of […]

Youth from lower socioeconomic backgrounds are more likely to develop heart disease as adults, partly because they face more challenges meeting physical activity, screen time, and sleep recommendations. This study will examine how improving these movement behaviours during adolescence could reduce future health inequalities. Using data from a long-term United States study that has followed […]

Many new mothers face uncertainty and a lack of support when making decisions about how to feed their newborns, especially in the early postpartum period. While breastfeeding is widely recognized for its benefits—such as supporting infant immune health, cognitive development, and mother-baby bonding—access to consistent guidance can vary greatly. Studies show that mothers with access […]

The expanding use of non-traditional vehicles has led to increasing trends of injuries and admissions to hospitals in many countries. Since these vehicles represent a new mode of transportation, the impact of their use is not clear due to limited number of studies that have been conducted, especially in Canada with its unique environments and […]

Trapped ultracold atoms are one of the primary platforms enabling the development of quantum computation and simulation. Continued scaling towards large, robust quantum mechanical systems relies on our ability to exert increasing levels of control over these atomic systems. The team working on the Rubidium-87 experiment at Collège de France have demonstrated unprecedented precision manipulation […]

This project explores how the brain transforms visual information, like colour, into spatial formats when storing it in memory. Using functional MRI (fMRI), we will study how these transformations happen and which brain areas are involved. This research builds on previous studies using EEG, but fMRI will provide a clearer picture of the brain regions […]

A key goal in modern organic chemistry is the development of efficient synthetic routes to access industrially relevant structures starting from highly abundant feedstock chemicals, while minimizing the use of expensive rare-earth metals for catalysis. This project aims to synthesize urea-type containing heterocycles, which are a common structural feature found in many biologically active compounds, […]

Given advancements in medical and surgical technology, the number of children with medical complexity (CMC) is rising. These children, who experience multiple chronic medical conditions and require ongoing specialized therapies, are at higher risk of adverse outcomes from respiratory infections. However, most research on respiratory infections among CMC has been limited by small sample sizes. […]

Security Operations Centers (SOCs) are responsible for detection and review of malicious interactions. The SOC issues tickets for interactions that are considered suspicious or threatening. These tickets are then inspected by analysts for approval. For sake of safety, this ticketing system often issues too many “false positives”, i.e., it alerts for interactions that are not […]

Recent studies in quantum computing have demonstrated that the localized unitary Jastrow (LUCJ) ansatz, a promising electronic structure method capable of running on near-term quantum hardware, can surpass exact solutions on classical hardware by using quantum-centric supercomputing. However, scalable and efficient methods for initializing the LUCJ ansatz remain underexplored in current research. We propose a […]

The Radiation Medicine Program at the Princess Margaret Cancer Centre treats cancer patients with Radiation Therapy (RT). RT relies on the principle that the cancer can be killed by delivering a high radiation dose to the tumor while sparing healthy tissues. Deformable image registration (DIR) is a cornerstone of modern RT, enabling the alignment of […]