UranOS: a Cloud-based Resource Management Framework for High Dimensionality Search Optimization

Multidisciplinary automated design-optimization (MDO) is a rapidly growing field of interest in sectors as diverse as architecture, engineering, science, and more. Often the computational cost of doing such optimization can be staggeringly high, requiring hundreds of computers connected through high-performance networks with complex custom designed software to support it. To address these problems, we propose […]

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Learning to organize and discover biomedical scientific literature

This project will investigate machine learning methods to organize and discover the vast literature on biomedical science. First, it will focus on named entity recognition–the task of finding and classifying entities in text documents–on large collections of abstracts and full-text of research papers and investigate semi-supervised learning methods to leverage large collections of unlabeled research […]

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Evaluation of National Physical Activity Initiatives

In 2007, ParticipACTION was relaunched in Canada with the goal of inspiring and supporting active living and sport participation for Canadians. The focus of ParticipACTION is on social marketing initiatives The objective of the proposed internship is to take advantage of data collected through internal evaluations commissioned by ParticipACTION of two national campaigns – Teen […]

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Advanced investigation of amphoteric reagent-based cyclization of peptides

Encycle Therapeutics is a Toronto-based company that develops new therapeutics for the treatment of autoimmune diseases. Our competitive edge derives from a platform technology that allows for the more efficient synthesis of macrocycle- (ringlike peptides) based therapeutics. This platform involves a proprietary reagent called aziridine aldehyde. This new technique has demonstrated significant potential for the […]

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A Novel Design of High Temperature Ultrasonic Transducers, Manufacturing, and Testing

The project objective is to design and manufacture ultrasonic sensors capable of operating at temperatures up to 800 oC. Such transducers can be affixed to hot piping systems and pressure vessels in petrochemical plants, electrical power generating stations, and manufacturing plants. These sensors can then provide continuous information to the plant operator regarding the onset […]

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Intramucosal Lorazepam spray: Whole Cell and Extracellular Eelctrophysiological Study of Pharmacokinetics and Pharmacodynamics

Epileptic patients have a long term risk of recurrent seizures and the mainstay of treatment for controlling seizures is antiepileptic drugs. Management of epileptic emergencies usually requires hospitalization and the administration of intravenous (i.v.) anticonvulsant drugs. Lorazepam i.v. is the most effective treatment of status epilepticus, and therefore is routinely used in hospital emergency departments. […]

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Modelling pollutant removal processes for an underground detention chamber system

This project will determine if underground detention systems provide an equivalent level of service for stormwater treatment as stormwater management ponds. This will be achieved through water quality measurements collected from a StormTrap system and through the development of a pollutant-transfer model. The intern will work with both the Toronto Region Conservation Authority and Con […]

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Otoscopy and Ophthalmology Training Technology Development

Teaching medical students and allied healthcare professionals accurate and patient friendly diagnosis of ear, eye and nasal conditions are challenging tasks due to the lack of realistic models and interaction with patients. The OONTTDP is a collaboration between the Hospital for Sick Children and Otosim to improve the teaching results through development of realistic simulators […]

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Novel application of deformable image registration using Computed Tomography for early diagnosis of lung parenchymal disease: focus on lung fibrosis

We aim to optimize advanced Computed Tomography (CT) imaging to provide non-invasive and accurate assessment of early lung fibrosis. Lung fibrosis causes inflammation and scarring of lung tissue and can be progressive, even fatal. Currently, detection of lung fibrosis relies on relatively insensitive tests, such as pulmonary function tests and static lung CT. Alternately, microscopic […]

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