Drug resistance of medically relevant microorganisms poses a grave threat to human health and has severe economic consequences. Fungal pathogens pose an additional complication as they are closely related to their human host. Current therapies to treat fungal infections are limited and drug resistance has already emerged in the clinic. We have conducted extensive research […]

Infectious diseases from a variety of pathogens can lead to serious health conditions such as sepsis. To improve the prognosis and decrease the mortality rate of infectious diseases, point-of-care testing (POCT) of blood biomarkers is a critical approach. Testing of biomarkers such as C-reactive protein, IL-6 and procalcitonin could help identify the type of pathogen […]

This research project aims to provide a robust account of school performance across Canada by collecting and measuring data on six critical indicators. These indicators are academic achievement, physical and mental health, social-emotional development, creativity and innovation, citizenship and democracy, and school climate. To address this inquiry, survey data will be collected and integrated with […]

Many genetic diseases caused by small genetic mutations do not result in complete loss of protein fnction, but rather are due to the degradation of mutant protein by a “quality control” mechanism (endoplasmic reticulum-associated degradation-ERAD) soon after it is made. Prominent amongst such ERAD-dependent diseases is Cystic Fibrosis(CF), a chronic, progressive, life-threatening genetic disease that […]

More than 25% of the fatal and injury car crashes are related to fatigue or drowsiness. This calls for the need for designing automated driver monitoring systems, which can continuously measure the drivers’ vigilance level and alert them if their cognitive state is not safe for driving anymore. One of the most reliable solutions is […]

As the Canadian population is aging, more and more Canadians will show cognitive decline. Aging and certain types of neurological disorders is often associated with deficits in executive functions: goal maintenance, planning, task switching and attention. These functions are critical for the maintenance of functional independence. Few validated rehabilitation approaches for these types of deficits exist. One […]

The proposed research project investigates two transnational teacher communities between Ontario and Shanghai secondary schools. Teachers’ cross-cultural professional learning is the focus of the study. To understand how, why, and what teachers learn from each other, the project needs to collect data from both countries. While in China, data collection will be completed in two […]

The proposed research project investigates two transnational teacher communities between Ontario and Shanghai secondary schools. Teachers’ cross-cultural professional learning is the focus of the study. To understand how, why, and what teachers learn from each other, the project needs to collect data from both countries. While in China, data collection will be completed in two […]

Recent years have witnessed a boom in the construction of modern high-rise buildings in megacities around the world. It is important to design a high-rise building that can effectively withstand both wind and earthquake loads. Nonetheless, in current practice, the design of highrise buildings for wind and earthquakes is done independently. Hence, there is an […]

Poor drug accumulation at tumor sites negatively affects the efficacy of many anti-cancer therapeutics. Development of non-invasive strategies that can effectively monitor drug biodistribution is important, especially given the increasing number and complexity of nanotherapeutic agents in clinical development. The use of positron emission tomography in conjunction with a radiolabeled drug delivery system has the […]

Osteoarthritis is a slow and progressive degenerative joint disorder, and is the most common form of arthritis, causing a significant reduction in the quality of life of afflicted individuals. A common treatment for this disease is to inject corticosteroids, such as triamcinolone acetonide (TA), directly into affected joints, which treats the joint inflammation that causes […]

Parent-child interaction significantly impacts child language learning and influences what is considered appropriate when communicating with others, which can vary from culture to culture. These caregiver-child interactions become extremely important when the child has a hearing loss. However, if the expectations of the family differ from those of the therapist serving the child, there could […]