Discovery of ligands for disrupting the SARS-CoV-2 interactome with human proteins using multipronged genetically encoded technologies

The proposed project will accelerate the drug development capabilities of 48Hour Discovery INC (48HD) to find high affinity drug candidates for treatment of COVID. The deliverable for this project will be high potential new drug candidates from 48HD’s drug discovery pipeline for COVID and other targets using unique molecular libraries of 48HD. The libraries are […]

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Activity-based screening of DNA-Encoded libraries

Cell surface receptors are targets of ~50% of pharmaceutical and biological drugs. Still many of such receptors have no known therapeutic inhibitors because 1) the receptors are only active in cells 2) isolation and purification of the receptor is not viable and 3) determining activity of a potential therapeutic is complicated by binding that can […]

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