The COVID-19 pandemic is a global health crisis on an unprecedented scale, with over 1 million confirmed cases, spread over 200 countries. With the world at a virtual standstill, and no existing treatments, there is an enormous need for novel therapeutics and vaccines to combat COVID-19. Our group is working on a DNA vaccine strategy […]

Gene therapy has the potential to effectively treat a wide range of ocular disorders. However, the introduction of foreign therapeutic genes to cells is incredibly challenging. Compared to viral vectors, non-viral vectors (NVV) are far less immunogenic and less toxic. However, NVV are less efficient than viral vectors at delivering therapeutic genes because they must […]

Despite the power of gene therapy, its successful application to medicine has been diminished due to: (i) high toxicities and potentially fatal adverse effects; (ii) poor transgene expression in target cells; and (iii) extensive vector degradation. While viral vectors greatly improve efficiency, they sometimes lead to cancers due to chromosomal integration and may suffer from […]

Mediphage Bioceuticals aims to leverage its DNA ministring platform for personalized genetic medicine. Mediphage Bioceuticals Inc. greatly appreciate Mitacs Accelerate program in providing support to (1) validate msDNA for gene delivery by carrying out a two-phase study, (2) develop and validate phage display libraries for the specific targeting and delivery to target host cells, and […]

Despite the power of gene therapy, its successful application to medicine has been diminished due to: (i) high toxicities and potentially fatal adverse effects; (ii) poor transgene expression in target cells; and (iii) extensive vector degradation. While viral vectors greatly improve efficiency, they sometimes lead to cancers due to chromosomal integration and may suffer from […]