Understanding the impact of changes to blood donation deferral screening and criteria for men who have sex with men – Year two

Available evidence suggests that up to 71% of individuals will require blood or blood products at some point in their lives. To meet this demand, Canadian Blood Services estimates that approximately 100,000 new donors are required annually. However, current blood donation guidelines in Canada require a 3-month deferral period for men who have sex with […]

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Program evaluation for JUMP Math: An empirical assessment of a resource for math education – Year two

Canadian math scores are in decline. Numerous studies have demonstrated the importance of numerical proficiency for outcomes such as health, employability and financial stability. Therefore, the effectiveness of a child’s math education is key to future success. It is of utmost importance, then, to identify effective math education programs. The proposed project will evaluate JUMP […]

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Accelerating discovery through high-throughput experimentation and machine learning – Year two

Canonical methods of molecular discovery and reaction optimization rely on “trial-and-error” approaches and slow experimentation with low discovery rates. By harnessing high-throughput experimentation (HTE) with machine learning (ML) methods, artificial intelligence (AI) and robotics, we have the potential to dramatically accelerate the discovery and preparation of next generation molecules and materials. We will extract, unify, […]

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Development, implementation and validation of new anti-E6 therapeutics for the treatment of HPV-associated cancer – Year two

Human papillomaviruses (HPVs) are responsible for almost all cervical cancers. Current treatment available relies on chemo- or radiation-therapy or surgery. These methods have several side-effects with high morbidity and survival of just ~ 70%. Our lab, therefore, develops a more patient-centered approach based on targeting the viral E6 protein, the main culprit of carcinogenesis in […]

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Process Development of Atomic Layer Deposition Cobalt and Ruthenium Metal Films – Year two

Next-generation integrated circuits require the innovation of new interconnect materials in order to maintain the performance improvements of Moore’s Law scaling. Cobalt (Co) and ruthenium (Ru) are two specific metals that are garnering strong interest for use in the filling of interconnects because of their better electrical performance and reliability at the extremely scaled dimensions […]

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Machine learning assisted quantum chemistry for Orquestra

Unsupervised machine learning has recently been introduced into the field of quantum many-body physics. A strategy based on generative models has been particularly successful in the data-driven learning of quantum states. In this proposal, we aim to adapt this technology to applications in quantum chemistry. The primary focus of this research will be on the […]

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Safety and effectiveness of Mifegymiso® offered through different service delivery points: a national prospective cohort study

Medication abortion with mifepristone and misoprostol has the potential to advance women’s access to safe and geographically accessible abortion care. Improved access to medication abortion protects women’s right to health and supports women’s autonomy and agency. However, the over-regulation of mifepristone in much of the Global North has muted the promise of this pill-based regimen […]

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Development of new methods for screening bioilogics by means of Capillary Electrophoresis (CE) coupled with Mass-Spectrometer (MS) via novel Open Port Probe Sampling Interface (OPP)

The methods for screening complex biological samples found wide application in pharmaceutics, forensic science and medical science. The majority of these methods involve several analytical techniques coupled together in order to maximize the efficiency of the analysis. For example, the combination of Capillary Electrophoresis (CE) with Mass Spectrometry (MS) creates a new analytical platform (CE-MS) […]

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Fischer–Tropsch Synthesis for Production of Synthetic Jet Fuel

Greenfield Global is developing a process to produce jet fuel from renewable materials, such as waste biomass and organic municipal waste. Fischer–Tropsch synthesis converts a mixture of carbon monoxide and hydrogen (synthesis gas) that was produced from the waste biomass and organic municipal waste into a synthetic crude oil that can be refined to produce […]

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