Improving vaccine production with novel drugs

Vaccination is the most effective method for the prevention of a wide range of human illnesses.  Vaccines are currently prepared by growing live virus strains in chicken eggs.  New strategies are very much needed to improve the speed and efficiency of virus production, especially during disease outbreaks.  Recently, Chem Virion has identified new drugs which […]

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Life cycle assessment (LCA) of Ontario Vehicle End-of-Life (VEOL) Processes

Life cycle assessment (leA) methods will be use to study end-of-life vehicle (ElV) dismantling and shredding processes, dismantling in particular, to identify and quantify the flows of EL Vs through these processes, as well as the El V parts and materials recovered for reuse, remanufacture and recycling. Understanding the eco-efficiencies associated with these activities, will: […]

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Multivariate Feature Extraction Methods for Biomedical Signals and Health Data Classification

In large health data sets, researchers may want to classify individuals into important groups, such as risk groups, based on multiple important variables from various different data resources.  Different groups may warrant different, targeted interventions.  Combining different data sources to classify individuals with the highest risks and needs can provide health officials an objective way […]

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Intraoperative Surgical Guidance for Neurosurgical Applications

Current intraoperative surgical navigation techniques are time consuming, may involve radiation and most importantly, are only able to account for patient motion during surgery a few times. The research project will focus on the development of an optical imaging device capable of capturing topographical images of exposed anatomical structures within the surgical field. These images […]

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Modelling of integrated biomass gasification and solid oxide fuel cell systems

Integrated solid oxide fuel cell and biomass gasification systems are one of the most promising energy technologies of the future. Usage of this system to utilize biomass yields better performance and environmental impact compared to the conventional biomass utilization technologies, e.g. steam turbine and internal combustion engine. However, to get the most benefit from this […]

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Towards a Cognitively Informed Music Knowledge Base

Music Information Retrieval is a burgeoning area of industry that assists consumers in retrieving information from increasingly large databases of music. waveDNA is an Ontario-based music software development company focused on building upon its proprietary algorithms for digital music representation and analysis in ways that make unique contributions to this field. The aim of the […]

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Statistical development for the analysis of longitudinal survey data from the International Tobacco Control project

There is an urgent need for developing and applying methods for analyzing longitudinal survey data. The proposed research aims to address that need with data from the International Tobacco Control (ITC) Project, which is conducting parallel longitudinal surveys across 20 countries to evaluate the impact of tobacco control policies (e.g., warning labels, smoke-free laws). These […]

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Fabrication and Characterization of Frisch Gridded Selenium Device

Amorphous selenium direct detection X-ray detectors coupled to amorphous silicon readout circuits provide the best spatial resolution and are the leading technology for the worldwide breast cancer imaging market.  However, they are relatively slow and noisy leading to higher X-ray dose requirements for the emerging and highly accurate modality of 3D breast imaging.  We plan […]

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Stoke-related slowing of balance reactions: Understanding mechanisms and developing treatments

Stroke    Canada's leading cause of chronic disability   often induces a condition of significantly reduced speeds of motion. Timely movements are, however, vital to prevent falls, perform daily activities, and be able to return to work. Therefore, our objective is to characterize `stroke-related slowing' and to suggest novel therapies. Balance characteristics during perturbed standing will be […]

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Developing Fluorescent-based Monitoring Strategies to Identify and Reduce Membrane Foulants in Drinking Water Treatment Applications

Membrane processes are increasingly used for the production of drinking water, representing a clean and efficient technology.  The application of membrane processes is limited by the accumulation of fouling components at/near the membrane surface and constitutes membrane fouling.  Therefore, fouling monitoring and control strategies are necessary to ensure sustainable operation of membrane processes.  In collaboration […]

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Using Natural History Collections to Shed Light on Long-term changes in colour, diet, and the effect of global climate change on seabirds

Global climate change threatens to drastically alter the behaviour and fitness of many species, and the ability to predict how Canadian wildlife will respond to these changes is imperative in planning management strategies. In this study, we will examine long-term changes in bill colouration, diet, and abundance of the Atlantic Puffin. We will collect feathers […]

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Mathematical modeling of Listeria overgrowth phenomenon

The standard method to test for Listeria n7onocj'logenes in foods is prone to false negatives if also non-pathogenic members of the Listeria genus are present. These can overgrow L.monocylogenes during the selective enrichment process and mask the presence of the pathogen. This "overgrowth'" phenomenon is not well understood, partially because the mathematical models that are […]

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