Reliable communication over wireless channels has been an active research area for decades. By employing multiple transmit and receive antennas, multiple-input multiple-output (MIMO) systems increase the capacity of a wireless channel, bringing significant gain over single-input single-output (SISO) systems. One of the main tools to achieve the improved capacity are error correction codes. During the […]

Membrane proteins such as ion channels, transporters or G-protein coupled receptors (GPCRs) are excellent but difficult drug targets involved in a large number of life-threatening diseases and conditions. These proteins, over-expressed and essential for disease onset and progression, are naturally targeted by toxins from venomous organisms. During evolution, these toxins have been optimized to efficiently […]

Governments around the globe are trying new approaches to solving complex social problems. They are increasingly moving away from the direct provision of social services towards more collaborative partnerships with the private sector. Pay-for-success, also known as pay-for-performance or Social Impact Bonds, is a method for engaging the private sector that has been gaining attention […]

The aim of The Ontario HIV Treatment Network (OHTN) is to help combat the spread of HIV by supporting, conducting, and sharing the best research possible. This project will involve a novel analysis incorporating focus groups with front-line service providers and key informants to help determine the factors that most influence the perception of HIV […]

Today, due in part to changing economic and competitive procurement processes, sole and small as well as some medium sized architectural practices increasingly need to work in consortium in order to competitively bid for medium to large projects of different types. Currently, there does not exist specific guidelines customized for small and medium practices to […]

As manufacturing and resource-based industries face growing challenges, Canada’s future increasingly depends on advances in and sustainability of knowledge organizations. Knowledge-based workers comprise a growing proportion of the workforce today. More often than not, they work in the context of large-scale expert networks, spanning across different disciplines and organizations. They rely on software technologies for […]

This research project is being undertaken in partnership with The Evidence Network Inc. It will extend the company’s scientifically-based method of assessing the impact of innovation support programs to the clean energy innovation sector. To keep this kind of assessment method scientifically sound requires customization for each particular industry. The established methods have been widely […]

Hearing aids are now fully digital, advanced signal processors. Studies show that the sound quality of today’s hearing aids is important, and may impact how a hearing aid user enjoys music. Few tools are available for clinicians to measure hearing aid sound quality in daily practice. In this project, we will develop and implement a […]

Signaling through the Eph family of cell surface receptors is crucial for embryonic development and the maintenance of adult tissues. Given the central role of the 14 Eph receptors in controlling cell fate, it is not surprising that they also play a central role in oncogenesis and other pathological conditions. However, the signaling mechanisms of […]

Hypoxic cells comprise most aggressive and therapy resistant population in the tumors therefore targeting proteins that are essential for hypoxia survival is an effective novel anti-cancer treatment. We have an ability to generate highly specific humanized synthetic antibodies against target of choice. We will generate antibodies against proteins that promote hypoxia survival, test their effect […]

Hypoxic cells comprise most aggressive and therapy resistant population in the tumors therefore targeting proteins that are essential for hypoxia survival is an effective novel anti-cancer treatment. We have an ability to generate highly specific humanized synthetic antibodies against target of choice. We will generate antibodies against proteins that promote hypoxia survival, test their effect […]

Air pollution is a major concern in urban centers because not only does affect vulnerable populations, but also impacts the quality of life for urban dwellers. With the new implementation of the Air Quality Health Index (AQHI) by the Ontario Ministry of the Environment and Climate Change to replace the existing Ontario Air Quality Index […]