Collagen-based composite bioink development

The continuous world innovation in the manifacturing techniques led to the development of highly precise technologies such as 3D printing. This technique has been then further improved in such a way to print biomaterials and cells, with extreme precision. It constitute a significant innovation for tissue engineering research. Collagen, the most abundant protein of the […]

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AI-driven evaluation of clinical electroencephalographic (EEG) recordings

The proposed project is part of a large-scale collaboration between SFU’s Behavioral and Cognitive Neuroscience Institute (BCNI) and Fraser Health Authority(FHA) in the domain of AI applied to clinical electroencephalographic (EEG) scans recorded and evaluated in the process of diagnostic workup in FHA’s public hospitals (n>40’000). The key goal of the SFU/FHA collaboration is to […]

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Modulation de l’activité des réseaux de la corne dorsale de la moelle épinière par des systèmes en boucles fermées

Les réseaux neuronaux de la moelle épinière grâce à leur position à l’interface entre les structures cérébrales et la périphérie de l’organisme, jouent des rôles fondamentaux dans notre perception des informations sensorielles (réseau de la corne dorsale : proprio-, intéro- et extéroceptives) et la production de nos actes moteurs (réseau de la corne ventrale). Contrairement […]

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Remodeling of relaxin-3 contacts on somatostatin interneurons in the amygdala of a mouse inflammatory pain model: a CLEM study with array tomography

Le projet vise à élucider les mécanismes des douleurs persistantes, et leurs conséquences sur des pathologies émotionnelles associées (anxiété). Notre hypothèse est que les modifications de l’activité des aires cérébrales impliquées dans les douleurs pathologiques et l’anxiété mettent en jeu des voies nerveuses descendantes qui relient le cortex et la moelle épinière. Le projet s’intéresse […]

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Multiplexed quantitative proteomics approaches to characterize residual host cell protein impurities in biopharmaceutical processing

Many drugs, such as those made of antibodies, are produced using cells from bacteria and other organisms. Companies such as BioVectra use this approach to produce antibody drugs efficiently and cost-effectively. At the end of the production process, residue such as protein from the “host” cells (called host cell proteins, or HCPs) must be removed […]

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Optimization of Graphical User Interface for the Digital Pathology Workstation

The workflow of pathologists will soon be revolutionized with the introduction of digital pathology allowing pathologists to view tissue samples as a digital image on a computer workstation. Such a conversion from traditional microscopy will bring many benefits to the pathologist’s workflow aiming to boost significant efficiency as well as ergonomic benefits. However, much work […]

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Improving protein content in rice grains through prime editing

Protein deficiency is a major problem affecting large scale of the world’s population. Rice, the globally desired staple food, has low protein content (7-10%) in its grains. Though rice protein content is low compared to other cereals, it is highly desired due to the presence of highly nutritious and easily digestible glutelin protein. Grain Protein […]

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Advancing Bio-materials Production Services

Bio-materials can reduce our dependence on fossil fuels, greenhouse gas emissions and facilitate a rapid transition to a bio-based leconomy. Thus, developing novel and innovative technologies and products related to bio-materials sectors is crucial. This has !resulted in extensive research into the development of biomaterials. Most research efforts have focused on materials selection, ‘fabrication, and […]

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Engineered Polymers for Nucleic Acid Therapies

Nucleic acids such as DNA and RNA offer exceptional opportunities to fight against infectious and genetic diseases. To use nucleic acids effectively in a clinical setting, one needs to use effective delivery vehicles that can deliver the nucleic acids into the diseased cells. This project will develop effective delivery systems for this purpose. The delivery […]

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Genome-wide overexpression library in Giardia spp. for drug target discovery

Giardiasis is a foodborne and waterborne disease that affects people worldwide, and it causes enteric diseases with outbreaks of diarrhea in adults and children. There are a few drugs available for treating Giardia spp. infections and they are associated with low efficacy, adverse effects, and drug resistance is spreading. Hence, there is an urgent need […]

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Benchmarking and validation of two dosimetry software packages for radiotherapy applications.

Brachytherapy dosimetry is traditionally based on the American Association for Physicists in Medicine Task Group No. 43 report, referred to as TG-43. The TG-43 dose calculation formalism describes dose delivery around a single source centrally positioned in a spherical water phantom. Patient geometry, tissue compositions, and density heterogeneities are ignored, as are foreign objects such […]

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