There is no direct way to measure spinal loads, and existing methods are indirect and invasive; alternatively, musculoskeletal models can predict spinal loads accurately and economically. Existing musculoskeletal models of spine substantially simplify the spine and/or use optimization algorithms to estimate muscle forces. Thus, we aim to develop a subject-specific musculoskeletal model of the spine […]

Prostaglandin E2 stimulates bone formation in vivo and exerts its effects through the EP4 receptor. Unfortunately prostaglandin E2 and agonists for the EP4 receptor also cause unacceptable systemic side effects which have limited their clinical use as anabolic agents. We developed novel bone-targeting prodrugs that can deliver EP4 agonists selectively to bone and liberate active […]

Blood tests are highly sought after to enable earlier cancer detection. We previously developed a blood test for breast cancer that is in prospective clinical study in Alberta, Manchester (UK), Oklahoma (USA) and South Korea. The proposed project will investigate some clinical samples collected through this work to support the primarily focus of identifying biomarkers […]

Blood tests are highly sought after to enable earlier cancer detection. We previously developed a blood test for breast cancer that is in prospective clinical study in Alberta, Manchester (UK), Oklahoma (USA) and South Korea. The proposed project will investigate some clinical samples collected through this work to support the primarily focus of identifying biomarkers […]

le projet de recherche repose sur l’utilisation d’une approche complémentaire par phytothérapie afin de traiter le cancer buccal , limiter son évolution , améliorer sa prévention et la qualité de vie liée aux personnes qui en sont atteintes. l’étudiant aura pour tâche d’étudier l’effet anticancéreux de l’anéthol sur les cellules du cancer de la bouche […]

Bipolar disorder (BD) is a chronic psychiatric disorder with peak age of onset between 15 and 25 years. In clinical practice it takes over a decade from initial symptom presentation to accurate diagnosis, with such delays being linked to a range of adverse consequences. Therefore, finding early markers of vulnerability is essential. Familial history (i.e. […]

Girls with Turner syndrome (TS), a chromosomal condition in which a female has complete or partial absence of the second sex chromosome, present a unique group of patients, with an increased risk of cardiovascular disease. Since the mid 1900s extensive research has led to advancements in the treatment of Turner syndrome: growth hormone therapy can […]

People with chronic lung diseases must breathe with more force and with more breaths because their diseased lungs do not exchange oxygen as well. This occurs in interstitial lung disease, when the lungs are stiffer and in chronic obstructive pulmonary disease, when the airways are obstructed due to phlegm and swelling. The breathing muscles in […]

The core of the research is multi-technology devices that stimulate and record neurons, integrated photonic devices for micro-displays, and photonics-enabled computing hardware. The novel foundational technologies underpinning the research are foundry-manufactured integrated photonics platforms on silicon for the visible spectrum and advanced 3D printing of biological and other organic materials. Macro-scale systems (mechanical and electronic) […]

Brain-inspired computers are a developing technology that use biological foundations to inform computational processes. The study of complex brain circuitry is crucial for creating such technologies. However, progress is limited as neural circuits are difficult to study in vivo. Under the directorship of Joyce Poon, the Nanophotonics, Integration and Neural Technology department of the Max […]

My lab’s research projects involve developing integrated silicon photonic devices for both brain-computer interfaces and artificial intelligence computing hardware. My focus will be developing photonic computing hardware that is neuromorphic, meaning it emulates the way our brains work. My main objectives will involve developing and characterizing integrated photonic chip designs that involve functional and trainable […]

L’entérocolite nécrosante (NEC) est la plus commune et la plus meurtrière des maladies inflammatoires de l’intestin. Elle affecte 5 à 10 % des enfants prématurés ayant un poids inférieur à 1500 g. Le lait maternel constitue l’approche la plus efficace pour prévenir ou traiter la NEC. En effet, il a été montré que l’alimentation avec […]