The safety and quality of vaccine products are an integral requirement for all vaccine manufacturing and production. Most current tests are using laboratory equipment that requires trained personnel, equipment qualification, method validation, manual sampling, and testing at various stages of product manufacturing. However, the off-line testing is slow, often requires significant volume of material for […]

This research project will combine computational modeling, machine learning (ML) algorithms and whole-brain neural recordings (magnetoencephalography, MEG) to shed light on how the mechanisms underlying dynamic decision making are implemented in the human brain. Specifically, we will use the statistical framework of information theory to characterize inter-areal neural coupling and the direction of information flow […]

Vaccine antigen production is a process that entails numerous variables. In order to have a consistent and robust process, monitoring of process parameters and controlling output variables within a certain range is the best practice. To accomplish this objective, analytical tools are used, on-line, off-line, at line. Real time monitoring of the processes is advantageous […]

Breast cancer affects 1 in 8 women during their lives and is the second-leading cause of female cancer related deaths. The ideal treatment is breast-conservation surgery during its early stage to remove the cancer while conserving healthy parts of the breast. With current resection methods, on average, one out of every three women undergoing breast-conservation […]

Although cannabis was legalized in Canada for recreational use in October 2018, there remains no effective method to determine roadside cannabis impairment. The state of the art device for detecting cannabis use roadside is saliva-based which has several flaws, including the fact that THC remains in saliva up to 72 hours after intake. In this […]

Diets which reduce carbohydrate intake and increase protein intake, such as Atkins diet, are popular and effective for weight loss. However, such diets may negatively affect cardiovascular health by increasing atherosclerotic plaque formation, and overall lead to higher mortality. Vuckovic and Bergdahl previously used mouse model that mimics spontaneous formation of atherosclerotic plaques in humans […]

Les stades les plus avancés du cancer sont caractérisés par la présence de tumeurs secondaires appelées métastases. Elles apparaissent suite à la dissémination de cellules tumorales dans l’organisme. Pour cela, les cellules tumorales acquièrent des capacités de migration et d’invasion. Les protéines de la famille des RhoGTPases sont impliquées dans ces phénomènes, il est donc […]

La presente recherche traite de l’evaluation des risques faisant obstacle a la liberte d’exploitation (FTO) d’un produit biologique, tel que levaccin XX d’influenza developpe par Medicago®. Elle correspond a la derniere etape du systeme de controle P.I. et a, notamment, pour objet d’identifier de nouveaux risques, mais egalement de mettre a jour taus les risques […]

The central problem of pharmaceutical research is to understand the effect of a certain molecule on human or animal biology. Many machine learning models have been developed in recent years and show great efficiency and accuracy for this kind of predictions. However, a problem common to many of the best algorithms is that they require […]

Our DNA exists in many different forms. The G-quadruplex is a type of DNA structure made from four strands of DNA. These structures are highly stable and potentially form throughout the genome at clinically important sites. To understand how G-quadruplex structures form, we need to investigate the physical forces that hold the molecules together. When […]

Conventional drug delivery methods, including oral ingestion and injection, distribute the drug to the entire body, reducing the amount of the drug delivered to the target tissue or organ and increasing side effects. Targeted drug delivery, in which the drug is transported directly to the target tissue or organ, can be used to minimize these […]

Research into wearable systems, functional nanomaterials, 3D printing, flexible microfluidics, and commercial thermoplastic polymer (TP) microfluidics, is reported daily. However, much of this research is hindered by difficulties in integrating structures, devices, and systems realized using different materials platforms. While polymers such as SU-8 and polydimethylsiloxane (PDMS) are popular with academics, TPs such as optically […]