Dental hygienists (DH) are exposed to many potentially injurious physical demands, such as prolonged exposure to awkward neck, trunk, and shoulder postures. The prevalence of musculoskeletal disorders in this group is alarmingly high (62-93%). DH would benefit from ergonomics-specific workplace safety education, but it is unknown what sort of instruction, if any, is currently offered […]

It is not well known that the majority of breast cancer patients do not receive a survival benefit from chemotherapy. Yet, they experience many negative short- and long-term side effects from chemotherapy. This is also the case for other cancers. There is thus a clear, unmet need for a diagnostic tool that can reliably identify […]

While chemotherapy drugs are effective in combating tumour growth in cancer patients, many such drugs permit the development of drug-resistant tumours and progression of the disease. We have observed that several chemotherapy agents induce the degradation of tumour cell ribonucleic acid (RNA) in the laboratory and in cancer patients. We have further shown that this […]

The goal of neurosurgery are two folds, 1) to achieve maximal resection of the target lesions, but simultaneously 2) minimize damage to adjacent healthy brain tissues. Currently surgeons rely on preoperative images such as Magnetic Resonance Imaging to define tumor boundaries. However, the accuracy of such images decreases intraoperatively due to brain shift. For these […]

Peritoneal Mesothelioma (PM) is a rare type of cancer affecting the protective membrane surrounding the abdominal cavity and the second most common type of mesothelioma, consisting about 10-20% of the diagnosed cases. The underlying cellular and molecular mechanisms of peritoneal mesothelioma pathology are greatly understudied. In this proposal, we aim to enhance the current knowledge […]

The success of Mycobacterium tuberculosis (Mtb), the infectious agent of tuberculosis (TB), lies in its ability to primarily infect, reside, and multiply in the lungs of patients. Mtb infects white blood cells termed alveolar macrophages and hides from the host immune response as well as from many antibiotics used for treatment, creating additional challenges for […]

There is a critical need for new therapies for Parkinson’s Disease (PD), a devastating neurodegenerative disease. Current therapies for PD treat disease symptoms, but do not provide a cure. The ability to generate patient brain-derived cells may rapidly advance development of personalized therapies for PD and other incurable neurological disorders. This study will use brain […]

It has been established that foam rolling can increase range of motion, reduce exercise-induced soreness and improve performance. An imbalance of hamstrings to quadriceps strength is associated with an increased incidence of lower limb injuries. The effect of rolling one muscle (e.g. quadriceps or hamstrings) or a pair of muscles on the antagonist muscle has […]

Ticks contain many different disease-causing bacteria and viruses, including the bacteria that causes Lyme disease. Multiple infections with these other pathogens in addition to Borrelia cause more severe illness. For many of these pathogens there are no or limited diagnostic tools available to detect the pathogen. This project includes production of a new product, “a […]

Les services de soins et de maintien à domicile comptaient sur un budget de 5,9 milliards de dollars en 2010, soit environ 4% des budgets publics en santé et sont en pleine expansion puisque qu’en 2011, 1,4 million de Canadiens en bénéficiaient, soit 55% de plus qu’en 2008. Le modèle de revenu pour la prestation […]

The intern will conduct a research study to evaluate whether measuring insulin in saliva can be used to reflect levels of insulin in the blood. The long-term objective is to work with the industry partner to develop a non-invasive personal salivary insulin monitor using a new technology that is in development that can quickly and […]

Qu Biologics is a clinical-stage biopharmaceutical company developing and evaluating an innovative immunotherapeutic approach to treating disease rooted in immune pathology/dysfunction. Qu’s proprietary technology platform, site-specific immunomodulators (SSI), act to stimulate the body’s own immune system to reverse the chronic inflammation underlying many conditions including cancer and immune-mediated diseases. For lung diseases, Qu’s platform SSI, […]