Des millions de Canadiens peuvent souffrir d’infections microbiennes au niveau des dents. Notre recherche vise le développement d’une nouvelle façon de traiter ces infections. Nous étudierons l’efficacité d’un produit nommé la dermaseptine à réduire la croissance des bactéries responsables des infections au niveau de la bouche et des dents. Si ce produit est efficace contre […]

The project will undertake independent and evidence-based research on the effects of exposure to low-dose radiation (LDR). It aims to obtain accurate and unbiased information on the biological responses resulting from exposures to LDR – a cell and tissue stressor. The project will undertake tasks that will identify changes in metabolic processes and physiological systems […]

Microplastics (MP), defined as any plastic polymer particles

Les facteurs de croissance stimulent la prolifération cellulaire. Ils agissent à travers des récepteurs situés à la surface cellulaire et activent des réseaux de signalisation complexes menant à l’expression des gènes. Un contrôle particulièrement efficace de cette signalisation s’exerce par le retrait du récepteur de la membrane plasmique par endocytose. Nous avons récemment montré que […]

Animal experiments have made significant contributions to medical advances. However, there is increasing awareness in the scientific community that animal studies are not always carried out with utmost efficiency. When study design is suboptimal and/or errors are made, there is a risk that incorrect conclusions are drawn, and that time, money, and animal lives are […]

Studies related to the gut-lung axis have spiraled in the recent year, especially with current challenges related to COVID-19. The role of an optimal microbiome status for a well-functioning immune system is now emerging as a crucial factor to protect against immune-deregulation and infection in sites distant from the intestine. Therefore, this project aims to […]

In nature, animals must make decisions about where to find food. Looking for food, however, exposes animals to the risk of being eaten by predators and forces them to compete with other animals for food. This combination of risk and competition is stressful, and animals respond by releasing hormones help them cope. Initially, a common […]

Healthcare professionals treating trauma patients can vicariously experience trauma from long term exposure to suffering, resulting in compassion fatigue. The impact of compassion fatigue on the psychological well-being of healthcare workers is detrimental, decreasing patient care and retention of healthcare providers. In an effort to reduce compassion fatigue, Mount Sinai Hospital has implemented a 4-hour […]

Protocells are synthetic, cell-like microcompartments designed to mimic key aspects of living cells to provide researchers with deeper insights into primitive cellular functions and behaviours. This research project is aimed to design and synthesize functional polymer coated gold nanoparticles and clusters (AuNP and AuNCs) that are capable of self-assembly into gold inorganic functional colloidosomes. The […]

Candida auris est une nouvelle espèce de Candida découverte depuis 2009, qui s’est propagée dans six continents, causant des épidémies nosocomiales de candidoses invasives. La mortalité élevée et la transmissibilité rendent C. auris un pathogène fongique dangereux pour la santé publique. De plus, C. auris peut développer des résistances à toutes les classes d’antifongiques (azoles, […]

Au Québec, il existe encore peu d’études évaluant les effets aigus et chroniques des herbicides sur les plantes aquatiques enracinées. Une meilleure compréhension des effets des activités agricoles sur les herbiers aquatiques, particulièrement ceux du Lac St-Pierre, est nécessaire à une gestion/conservation adéquate de ces écosystèmes de grande valeur. Ce stage portera en grande partie […]

Having an efficient and scalable manufacturing production process of Adeno-Associated Virus (AAV) vectors remains one of the most challenging problems in the industry for meeting the high demand of AAV for clinical application in gene therapy. The current production process of AAV relies on the co-transfection of three plasmids containing the main virus structural and […]