Encycle Therapeutics is a Toronto-based company that develops new therapeutics for the treatment of autoimmune diseases. Our competitive edge derives from a platform technology that allows for the more efficient synthesis of macrocycle- (ringlike peptides) based therapeutics. This platform involves a proprietary reagent called aziridine aldehyde. This new technique has demonstrated significant potential for the […]

The Cat-SPIRE vaccine reduces symptoms in those who suffer from cat allergy. Two interns will work on complementary projects that will evaluate blood and nasal biomarkers of Cat-SPIRE efficacy. One trainee will examine changes to the DNA in special immune cells called dendritic cells, isolated from blood. The other trainee will examine markers of inflammation […]

This proposal describes a multidisciplinary approach to optimize the separation of peptides from an enzyme digest of filleting waste (frames) recovered from farm-raised Atlantic salmon. Our work has demonstrated that a particular salmon peptide fraction has the ability to reverse the effects of type 2 diabetes in rodent feeding trials and model system (tissue culture) […]

Epileptic patients have a long term risk of recurrent seizures and the mainstay of treatment for controlling seizures is antiepileptic drugs. Management of epileptic emergencies usually requires hospitalization and the administration of intravenous (i.v.) anticonvulsant drugs. Lorazepam i.v. is the most effective treatment of status epilepticus, and therefore is routinely used in hospital emergency departments. […]

Cancer is one of the leading causes of death worldwide with approximately 8 million deaths in 2010. Most cancer treatments lack specificity and affect the whole body, with toxic effects on both cancerous and normal cells. Although new therapies are emerging, targeting cancer cells is a challenge because of the lack of specific markers on […]

We aim to optimize advanced Computed Tomography (CT) imaging to provide non-invasive and accurate assessment of early lung fibrosis. Lung fibrosis causes inflammation and scarring of lung tissue and can be progressive, even fatal. Currently, detection of lung fibrosis relies on relatively insensitive tests, such as pulmonary function tests and static lung CT. Alternately, microscopic […]

The healthcare system in Canada and world-wide is suffering increased pressure due to an aging population and increased rates of chronic disease. Research shows that self-management and social networks are key indicators for reducing utilization and cost and improving outcomes of healthcare systems. Lifeguard Health Solutions Inc. has developed a mobile health application that uses […]

The proposed project is for the intern to develop an algorithm to decide on the suitability of a group of chemical compounds to transfer from one detection instrument (low throughput) to another detection instrument (high throughput). For ease of use and cost considerations it is preferable for these chemical compounds to measured using a high […]

Expressing Vibrancy is a yearlong project outlining an approach for measuring the cultural vibrancy of neighbourhoods. The proposed research seeks to develop methods for understanding and measuring the cultural vibrancy of neighbourhoods, using Hamilton, Ontario as a case study. Using innovative technologies (geo-referenced video), this project will analyze the relationship between measures of cultural vibrancy […]

We will assess the quality and suitability of blood and blood-derived products using a fast and economical approach that combines measurements of molecules in the blood product identified by their weight and computational approaches to make sense of all the data generated. Normal blood products have thousands of small molecules in common. By monitoring a […]

The purpose of this 4‐month internship is to scale‐up the bionanofluid production at McGill University and then transfer this process to Leap Medical Labs for commercialization. At McGill, this will involve the design and implementation of 2 new reactors, as well as testing, optimization and validation of the various process parameters. Once the scale‐up is […]

Vaccination is an important preventive measure against influenza infection during both seasonal epidemics and pandemic outbreaks. This research aims to understand the effect of early vaccination during influenza outbreaks. The objectives are to measure the effectiveness of early vaccination in terms of reducing disease burden (e.g., infection, hospitalization). We apply an important methodology, namely mathematical […]