Comprehensive Molecular Analysis of Pre- and Postmenopausal Human MammaryCells to Enable Their Optimized Growth as Organoids Ex Vivo – Year two

The goal of this project is to discover new factors essential for maintaining a normal human mammary gland. The approach is to generate and analyze in depth the protein-encoding RNAs and chromatin states that control their expression in the different types of cells that constitute the human mammary epithelium and its surrounding stromal cells. This […]

Read More
Ensuring Stability and Accuracy of Multi-rate Electromagnetic Transient Simulation

Real-time digital power system simulators are used for testing and debugging control equipment intended for field installation. They simulate the power network in ‘real-time’, i.e., the simulation computations are rapidly completed so as to retain synchronism with a real-world clock. This requires the level of complexity in different components of the network to be judiciously […]

Read More
Development of a specific targeted therapy for hepatocellular carcinoma

The global burden of hepatocellular carcinoma (HCC) is increasing as it has become the second leading cause of cancer-related deaths and the fifth most common cancer worldwide. HCC is heterogenous, arising in the setting of various chronic liver diseases such as hepatitis C, non-alcoholic fatty liver disease and cirrhosis. Patients with cirrhosis who develop cancer […]

Read More
Efficient Cutting for Haptic Surgery Simulation using Hybrid Deformation Models

This research project aims to expand Symgery’s line of surgical training products by simulating cutting and tearing of physical models in real-time. Cutting and tearing of simulated models typically requires additional computational overhead due to post-processing of the volumetric mesh. However, our approach will render the process to be more efficient by using a hybrid […]

Read More
Valorisation des plastiques usés par voie de composites formulés avec de la biomasse résiduelle

L’usage excessif des plastiques à l’échelle mondiale engendre de grands défis liés au control de la pollution, particulièrement dans les océans, mais aussi au niveau de l’empreinte carbonique de leur production. Dans le contexte de crise sanitaire actuel due à la COVID-19, les équipements de protection personnel sont nécessaires et leurs utilisation, obligatoire, a augmenté […]

Read More
Safe Unmanned Traffic Management (SafeUTM)

Unmanned Air Vehicles (UAVs) became ubiquitous in our everyday civilian lives for both recreational activities, such as sports, as well as film and photography. They have also been used in several military operations such as tactical reconnaissance. The prediction of a near future where drones will be used frequently for search and rescue, package delivery […]

Read More
Assessing hatchery related well-being of leghorn chicks

Most Canadian poultry originate at commercial hatcheries. Recently hatcheries have had concerns about chick welfare brought to their attention. Very little research has been performed that looks at the welfare of chicks at the hatchery or during transport to farm. During the proposed research project, the intern will look at three events that happen to […]

Read More
Wireless fiber-photometry headstage platform

Having a look inside of the brain helps us understand its mechanisms and can be done using different methods. One particular method used in mice is called fiber photometry which consists of placing small optical fibers inside a particular region of the brain and shoot light through that fiber into it. The different cells in […]

Read More
The influence of early-life gut microbiome disruption on HPA stress axisdysregulation and allergic asthma – Year two

Asthma affects 1 in 8 Canadian children and is the leading cause of pediatric hospitalizations with costs to Canadian health care systems estimated to exceed 4.2Billion/year by 2030. While the causes are still debated, infant prematurity is a strong predictor for asthma. The altered gut bacterial community (microbiome) in preemies is suspected to contribute to […]

Read More
Development of novel therapeutics for multidrug-resistant bacterial pathogens by targeting indel-containing essential proteins

Multidrug-resistant (MDR) bacterial pathogens are ubiquitous in hospitals and community settings. New antibiotics against unexploited targets are urgently needed to better control such infections. The proposed research aims to identify novel, drug targets and therapeutics for antibiotic-resistant nosocomial pathogens, capitalizing on a proprietary indel-targeting approach that takes advantage of structural differences between homologous essential human […]

Read More