Engineering WD40 Domain-Mediated Protein-Protein Interactions in DNA Repair for Cancer Therapeutics

Current cancer therapies rely on toxic chemotherapeutic agents that lack the potency and selectivity of protein-based therapy. Consequently, new technologies to systematically target cancer signaling pathways at the protein level are urgently needed. Dr. Zhang has developed a platform that consistently and successfully produces quick and cost-effective protein-based therapies that are both highly-binding and specific […]

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The effects of One to Zero Technique on neural function, health and well-being

The one-to-Zero (OTZ) Tension Adjustment is a chiropractic technique which corrects articular dysfunction of the articulation between the skull and the top vertebrae of the neck, also called the atlas. The goal of this study is to determine whether correcting dysfunction using OTZ affects brain processes and overall health and well-being. Participants will complete questionnaires […]

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Airway-On-A-Chip: Development and In Vitro Validation of A Microfluidic Cell Culture Model for Chronic Obstructive Pulmonary Disease (COPD)

Chronic obstructive pulmonary disease (COPD) is an inflammatory disorder of the lung, and one that affects 2.6 million Canadians and 380 million people worldwide. Although the disease affects a large population worldwide the therapies used for treatment remain imprecise. With the lack of disease modifying therapies there is a pressing need to discover novel targets […]

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PITCH – Proactive Integrated Tech-enabled Patient-Centric Healthcare

PITCH is a new initiative focussed on understanding new models for delivering sustainable and proactive health assessments with a focus on patient engagement. It is a collaborative program that includes computer scientists, engineers, data scientists, clinicians, home care providers, and industry partners. In this work, we aim to develop novel security, auditing, analysis and visualization […]

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Evaluation of corticosteroid-releasing nano- and micro-particles for pain management in osteoarthritis

Osteoarthritis is a progressive joint disease that causes pain and stiffness, resulting in a decrease in quality of life for patients. Treatment include intra-articular administration of crystalline corticosteroids or hyaluronate. Intra-articular corticosteroids, due to the large doses required, short residence time in the joint, and crystalline structure, are associated with cartilage damage and a short […]

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Understanding the role and regulation of follicular fluid miRNAs in ovarian function and polycystic ovarian syndrome. 1

The polycystic ovarian syndrome (PCOS), a multi-factorial heterogeneous syndrome with complex pathologies, affects up to 10% of women of reproductive age and accounts for 75% of anovulatory infertility. PCOS is associated with follicle growth arrest at the early antral stage, chronic anovulation, minimal granulosa cell proliferation, hyperthecosis with hyperandrogenemia, and insulin resistance. The proposed research […]

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Preventing medication errors in patients with low kidney function.

Patients with low kidney function need to take certain medications at a lower dose because their kidneys cannot filter the medication as well from the body. Taking medications at a high dose may be harmful to a patient and lead sometimes to death. The aim of my research is to help reduce medication errors in […]

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Integrative Multi-Omics to identify Therapeutic Targets for COPD

Chronic Obstructive Pulmonary Disease (COPD) is a common illness that affects millions of Canadians, yet there are no effective therapies to treat it. Genes play a role in COPD development, and our proposal aims at identifying those genes in lung tissue that cause the disease. The Providence Airway Centre is very committed at helping COPD […]

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Implementation and Analysis of Polymeric Pressure Sensor to Estimate Blood Pressure in the Brachial Artery

Automatic blood pressure monitors with inflatable cuff currently in use are inaccurate and produce inconsistent results. Even small movements during measurement can affect the measurement and lead to inaccurate diagnosis. This project aims to improve the accuracy of blood pressure monitors using advanced thin film sensors that can greatly improve the diagnosis. The project will […]

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The inhibitory effect of Aevo Oral Ultrasound Gel on dental bacteria

Dental caries affects the majority of the world’s population and causes tooth decay and loss. Bacteria in the mouth cause this disease. Sugar consumption plays a role in causing these bacteria to make acid that results in dental caries. Studies have shown that a type of sugar alcohol, called xylitol, can help prevent this disease. […]

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