Innovative Projects Realized

Explore thousands of successful projects resulting from collaboration between organizations and post-secondary talent.

13270 Completed Projects

1072
AB
2795
BC
430
MB
106
NF
348
SK
4184
ON
2671
QC
43
PE
209
NB
474
NS

Projects by Category

10%
Computer science
9%
Engineering
1%
Engineering - biomedical
4%
Engineering - chemical / biological

The anti-Helicobacter pylori properties and mechanism of action of probiotic Lactobacilli secretomes

Helicobacter pylori (HP) is a bacterium that causes 65% of gastric ulcers and cancers worldwide. Current anti HP treatments often fail because the bacteria have become resistant and they have serious side effects. We are looking into using molecules produced by bacteria called Lactobacilli that are a natural component of the human gastro-intestinal flora to treat and/or prevent Helicobacter infections. The novelty of our approach is to focus on the molecules that Lactobacilli release (i.e. their secretions) and that could be administered to patients in a controlled and reliable manner. Using the released molecules also facilitates determining the mechanism of action. We have compares the secretions produced by 25 Lactobacilli for their anti-HP effects and have identified very active strains. We propose to determine their mechanisms of action and identify the nature of the active molecules. TO BE CONT’D

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Faculty Supervisor:

Carole Creuzenet

Student:

Samantha Whiteside

Partner:

Lallemand Health Solutions

Discipline:

Biology

Sector:

Medical devices

University:

Program:

Accelerate

Characterization of striatal innervation by drNPC-A9 cells in a rat model of Parkinson’s Disease

Parkinson’s Disease is the second most common neurological disorder. Over the course of the disease the brain cells that produce dopamine are slowly dying. The loss of these dopamine-producing cells means that less dopamine is available in the brain, causing many symptoms such as tremors. Unfortunately, brain cells cannot regenerate, so a patient’s symptoms will worsen over time. In the current project we aim to investigate human dopamine cells (i.e. drNPC-A9) that were grown in a petri-dish by New World Laboratories. Pre-clinical studies have revealed that the injection of these drNPC-A9 cells in rats, can rescue Parkinson disease-like symptoms. In this project we aim to understand how these drNPC-A9 cells are able to do that. The acquired information will directly contribute to the development of a therapy for Parkinson’s Disease.

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Faculty Supervisor:

Louis-Eric Trudeau

Student:

Willemieke Kouwenhoven

Partner:

New World Laboratories Inc

Discipline:

Pharmacy / Pharmacology

Sector:

Medical devices

University:

Program:

Accelerate

Development and characterization of graphene/glass fiber/polyester composites

Polymeric matrices containing nano-size additives have demonstrated remarkable mechanical, electrical, and thermal properties when compared to their micro-composite counterparts. Inserting graphene in a polymer matrix consisting of a glass fiber-reinforced resin is assumed to significantly increase the material electrical conductivity, which is needed in order to fulfill electrical conductivity requirements traditionally met by carbon black incorporation. However, in order to manufacture such graphene-containing polymeric composites, three major processing challenges have to be overcome: re-agglomeration, graphene sedimentation as well as the increase in matrix viscosity. Accordingly, in this project, the effect of different grades of NanoXplore’s graphene on the morphology, electrical and mechanical properties of graphene/glass fiber/polyester composites will be investigated. The focus will be on interfacial interactions between filler and fiber; filler and matrix; fiber and matrix.

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Faculty Supervisor:

Eric David

Student:

Milad Madinehei

Partner:

NanoXplore Inc

Discipline:

Engineering - mechanical

Sector:

Automotive and transportation

University:

Program:

Accelerate

Improving the properties of active pharmaceutical ingredients by polymorph, salt and cocrystal screening

Solids exist as crystals, amorphous or subcooled liquids. The degree of crystallinity determines the long range order in a solid phase. Molecules when transferred from the solution to the solid phase may take many different crystal forms (polymorphs, solvates/hydrates, salts, co-crystals). Theoretically, there are 230 space groups describing the diversity of a crystalline material. About two thirds of pharmaceutical small molecules exist in more than one polymorphic solid form. Crystallization of polymorphs still has a touch of art. Various solid forms often display different mechanical, thermal, physical and chemical properties that can influence the bioavailability, hygroscopicity, stability and other performance characteristics of an API. The goal of this project is to unravel the inter- and intra-molecular forces that are responsible for the molecular packing, conformational polymorphism, and salt/cocrystal formation and therefore, predict and screen possible polymorphs, salts and cocrystals of a given API. This will be achieved by performing high-throughput experimentation to guarantee a product with desirable solubility, dissolution rate, and stability.

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Faculty Supervisor:

Sohrab Rohani

Student:

Pradip Mondal

Partner:

Solid State Pharma Inc.

Discipline:

Chemistry

Sector:

Pharmaceuticals

University:

Program:

Accelerate

Haptic API/SDK for Distributed Full Body Haptics

The research seeks to develop an easy to use and program SDK in the Unity software framework for the design and integration of expressive haptic effects for a distributed series of worn haptic actuators. The project’s central objective is to develop a cross platform composition tool for designers that makes it easy to integrate haptic effects into new kinds of XR-based immersive experiences ranging from games and VR experiences to full body, immersive room-based environments.

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Faculty Supervisor:

Christopher Salter

Student:

Enric Llagostera

Partner:

Phenomena

Discipline:

Computer science

Sector:

Media and communications

University:

Program:

Accelerate

Evaluation of corticosteroid-releasing formulations to suppress implant device- related foreign body reactions and fibrosis

Implanted medical devices have dramatically improved the lives of millions of patients worldwide. However, in many cases, the body’s immune system rejects these devices and encapsulates the implant in fibrous scar tissue. This reaction is most detrimental to sensors for continuous monitoring and treatment of chronic conditions such as diabetes and those of the central nervous system. Device functionality is usually severely limited and risky additional surgeries for implant removal and reinsertion are required. Local delivery of corticosteroid drugs such as dexamethasone have been shown to suppress the immune response and extend device life. Nevertheless, restrictions on device size and requirements for extended drug presence (up to 1 month) have limited corticosteroid utility to date. The objective of the proposed project is to develop novel corticosteroid releasing technologies that can be processed in forms suitable for sensor applications, in particular for those used in continuous glucose monitors.

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Faculty Supervisor:

Boris Hinz

Student:

Pardis Pakshir

Partner:

Interface Biologics Inc.

Discipline:

Engineering - biomedical

Sector:

Medical devices

University:

Program:

Accelerate

Implementation of MR/VR holographic rock mass mapping techniques in underground and surface mining.

Considerable advances in geological and rock engineering mapping methods using both conventional and remote sensing techniques have occurred over the last decade. The primary objective of the proposed research is to further develop the use Virtual and Mixed Reality (VR/MR), techniques in improving structural geological and rock mass field data acquisition. New uses of MR and Virtual Reality, VR, methods will be explored in combined field and office settings. The research will enhance the use of existing mine datasets both during mapping and subsequently in office data interpretation and mine design use. The internee will gain expertise in a wide variety of mine and office-based rock engineering techniques including state-of-the-art VR/MR and remote sensing methods. A major benefit to SRK will be the mine testing and further development of improved state-of-the-art mapping techniques and optimized exploitation and communication of mine datasets through the use of virtual reality platforms and mixed reality holographic image sets.

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Faculty Supervisor:

Douglas Stead

Student:

Emre Onsel

Partner:

SRK Consulting (Canada) Inc.

Discipline:

Geography / Geology / Earth science

Sector:

Natural resources

University:

Program:

Accelerate

Characterization and quantification of adsorbed antigens in adjuvanted vaccines

Vaccines are one of the most important medical breakthroughs, proactively saving millions of lifes and reducing human morbidity. Yet there remains a need to make current vaccine formulations more effective and affordable, which requires testing and optimizing new formulations. In addition, there remains diseases for which there are no efficient vaccine. To develop and test new vaccines or vaccine formulations, Sanofi Pasteur and other manufacturers often rely on animal testing. However, Sanofi Pasteur is committed to reducing animal testing by developing alternate in vitro assays that support vaccine efficacy. This project will aim to develop a method that uses specialized equipment called ImageStream to quantify vaccine components without undertaking processes that destroy these components. If successful, we may be able to use this approach to quantify and examine the quality of vaccine components, while avoiding or reducing the number of animals needed to test this.

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Faculty Supervisor:

Roberto Botelho

Student:

Christopher Choy

Partner:

Sanofi Pasteur

Discipline:

Biology

Sector:

Life sciences

University:

Program:

Accelerate

Progranulin as a potential therapeutic agent for neurodegeneration

Degenerative brain diseases, such as Alzheimer’s disease and Parkinson’s disease remain incurable despite intense research over decades. Progranulin, a protein that was identified and characterized in our laboratories and it has been shown to inhibit the development of Parkinson’s-like and Alzheimer’s-like symptoms in experimental models in mice by the partner organization Neurodyn. We believe that it has similar potential to forestall brain diseases in humans. A roadblock towards this goal is the complexity of the progranulin molecule. Our goal is to design simplified forms of progranulin, that retain its therapeutic potential, but which may be better adapted as the source of novel biologically-based drugs to combat brain disease.

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Faculty Supervisor:

Andrew Bateman

Student:

Babykumari Chitramuthu

Partner:

Neurodyn Life Sciences Inc

Discipline:

Medicine

Sector:

Medical devices

University:

Program:

Accelerate

Optimization of Angiotensin II Receptor type 1 Blockers (ARBs) in chronic obstructive pulmonary disease (COPD)

Chronic Obstructive Pulmonary Diseases (COPD) is a lung disease that cause a lot of suffering to the Canadian population. To accelerate the drug discovery process, an old blood pressure lowering medication was tested to block the progression of COPD. A patient study showed that the old medication did provide some protective effect to the lung airways of COPD patients. However, we have found that this old medication does not slow down COPD by lowering blood pressure, but rather by acting on a new, unknown target. As expected, we found that this old medication is an ‘average’ mediator of lung protection, and there are other medications in the same class of drugs that may provide better lung protection. We will assess these other medications and will also make some modifications to the structure of the old medication to improve its ability to protect the lung airways of COPD patients. Our innovative proposal to speed up the drug discovery process will benefit COPD patients and the management of their disease.

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Faculty Supervisor:

Pascal Bernatchez

Student:

Zoe White

Partner:

Providence Health Care

Discipline:

Pharmacy / Pharmacology

Sector:

Pharmaceuticals

University:

Program:

Accelerate

Development of a cricket growth accelerant

The major goal of this project is to develop a method to improve the production efficiency of cricket farming in the partner organization. Cricket farming has a potential to support the growing global population by serving as a rich source of animal protein. Many start-up companies are emerging, but the limited knowledge and experience in culturing cricket attenuates its yields. In this project, we will build on a recent scientific achievement by the intern. Dr. Miyashita discovered that honey bee royal jelly increases 1) body size, 2) survival, and 3) growth rate of crickets. We will first attempt to isolate the active ingredient by testing it on a laboratory colony. We will then develop an industrially scalable method to improve the Return of Investment (ROI) of the cricket farming.

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Faculty Supervisor:

Shelley Adamo

Student:

Atsushi Miyashita

Partner:

Midgard Insect Farm Inc

Discipline:

Psychology

Sector:

Agriculture

University:

Program:

Accelerate

Characterization of Carotenogenic Heterotrophs for Production of High-Value Antioxidants

The development of novel biotechnologies will be a key component of the economic growth and development of Canada’s changing economy. A critical component of this will be fostering the development of start-up companies that can capitalize on these new opportunities. The Myera Group is an indigenous-led company in Manitoba that is developing novel biotechnologies for Canada’s new economy. This project focuses on the development of microorganisms that can produce a profile of novel high-value carotenoids (chemically related to ?-carotene). These carotenoids have an array of applications as antioxidants and also may have a role in improving eye health. Sold either directly as a dietary supplement, or as an additive to functional foods, novel carotenoids is an emerging area with large growth potential. This project has the goal of taking the producing organisms from the academic ‘lab-bench’ (grams of product) of to the industrial process scale (kilograms of product). Success in this project will provide Myera Group with a unique revenue stream and foster future economic growth and development.

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Faculty Supervisor:

John Sorensen

Student:

Warren Blunt

Partner:

Myera Nu-Agri-Nomics Group Canada Inc

Discipline:

Chemistry

Sector:

Alternative energy

University:

Program:

Accelerate

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