Caractérisation biophysique et structurale des particules pseudo-virales issues de la technologie PAL

La technologie PAL, propriété de Folia Biotech, repose sur l’utilisation commerciale de particules pseudo-virales recombinantes (PPVr) du virus de la mosaïque de la papaye, comme (i) adjuvant et (ii) plateforme de vaccination. Plusieurs PPVr découlant de PAL ciblent diverses applications médicales. Par exemple, PAL-flu est un vaccin influenza saisonnier en phase clinique, tandis que PAL-Pan […]

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Characterizing the Mode of Action of Novel Boron-Containing Antifungal Agents for Crop Protection

Fungal pathogens of agriculturally significant crops pose a serious threat against global food security. This is exacerbated by the limited classes of fungicides that are commercially available for the farmers and the rapid emergence of resistance against the existing fungicides. Furthermore, resistance against agricultural fungicides can poses serious threat to human health as it can […]

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Bioorthogonal spin labeling approaches for high sensitivity electron paramagnetic resonance spectroscopy

In order to investigate proteins in their natural environment one can attach tiny reporter molecules to them that can be traced with appropriate instruments. However, these small reporter molecules may often cause strong perturbations to the functionality of the proteins, or cannot be seen due to experimental restrictions like low concentrations. Bioorthogonal chemistry aims to […]

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The Role of Natural Background Radiation on Neurological Development and Processes

All species on the planet are affected by their environment: temperature, atmospheric pressure, daylight hours, and so on. These conditions affect how a species react to stress, grow, reproduce, and survive. Natural background radiation (NBR) is ever-present and has been prior to the evolution of all species. In order to study the effect of NBR […]

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Accelerate development of new technologies and applications for advanced water treatment – Year 2

Global population growth, urbanization and changing climate patterns have increased the demand for potable water, wastewater reuse and value recovery from wastewater, and for remediation of industrial process water. Population growth also results in increased demand for the shipping of goods by ocean freight, with the associated risk of the transport of unwanted marine life […]

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Development of a next-generation in vivo human gene-editing therapeutic platform – Year two

The over-arching goal of our project is to develop a robust next-generation gene-editing platform to repair the deleterious mutations that are responsible for genetic diseases such as Cystic Fibrosis and cancer. First-generation precision endonuclease technologies have been tremendous for in vitro gene disruption studies and ex vivo treatments, but there has been limited success at […]

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Microalgae for the production of plant specialized metabolites of interest – Industrial PDF Fellowship Revision

Algae-C is a company specialized in algal biomass production. It enables on-site production of algae for a wide variety of sectors (aquaculture, nutraceutical, cosmetic and biofuel). To date, many fuels, pharmaceuticals and cosmetic products are extracted from plants. These valuable plant natural products (PNPs) are often produced in low quantities in plants and extraction methods […]

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Development and use of ezrin biosensors for high-throughput screening of novel ezrin inhibitors as anti-metastatic and immune-checkpoint blockade agents

Treatment of metastatic breast cancer is often unsuccessful and lead to 5000 deaths in Canada each year. Therefore, there is an unmet need for new drugs for prevention and/or treatment of metastatic disease. Ezrin is a protein marker commonly over-expressed in metastatic breast cancer. Preclinical studies show that blocking ezrin can significantly reduce metastasis in […]

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Development of a softab nutraceutical formulation

Softab Technologies is a fast-growing company in Windsor, Ontario that is developing new formulations and methods to provide nutraceuticals: vitamins, natural extracts, and minerals in a revolutionary new form of chewable and dissolvable gel. They are working with a research team in the Department of Chemistry and Biochemistry at the University of Windsor to refine […]

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Employing Raman Spectroscopy for monitoring a vaccine manufacturing process

Vaccine antigen production is a process that entails numerous variables. In order to have a consistent and robust process, monitoring of process parameters and controlling output variables within a certain range is the best practice. To accomplish this objective, analytical tools are used, on-line, off-line, at line. Real time monitoring of the processes is advantageous […]

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Enhancement of Canine Adipose Tissue-Derived Mesenchymal Stromal Cells Immune-Modulatory Properties and In Vivo Feasibility Testing in Elbow Dysplasia Patients

Osteoarthritis is a major cause of disability in dogs. Today, the therapeutic role of mesenchymal stromal cells (MSCs) as a potential treatment for immune and inflammatory disorders is well-defined. We are interested in exploring the immune-modulatory property of canine MSCs with the aim of exploiting it as a potential therapy in dogs with Elbow Dysplasia. […]

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