Development of new classes of bio-relevant linkers for PROTACs and other conjugates using new technologies – Year two

Les PROTACs sont de nouvelles molécules thérapeutiques ayant pour but de soigner certaines maladies grave comme les cancers. Ces composés sont des molécules linéaires constitués de trois composants principaux : une extrémité permettant de repérer la cible, une autre extrémité permettant de causer la dégradation de cette cible, et enfin un linker reliant les deux. […]

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Hydrorefined fuels – computational insight into the mechanism

Improving the quality of fuels, increasing the efficiency and also producing lower emissions is one of the main challenges of the 21st century. A Calgary company, Katal, is working on a hydrorefining process in order to produce diesel fuel with superior quality compared with the traditional fuel. The company, however, has limited scientific understanding of […]

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Generation and characterization of novel small molecule protein degraders in oncology

Many patients who initially respond well to highly efficacious chemotherapy eventually develop resistance and relapse despite continued treatment. These cancers acquire drug resistance to current therapies through various mechanisms such as the acquisition of mutations for example. Furthermore, some promising targets that play a crucial role in the progression of cancer have been deemed undruggable […]

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Advanced differential mobility mass spectrometry with electron capture dissociation for the characterization of therapeutic proteins – Year two

Many new pharmaceuticals are based on large biomolecules like proteins. Even small differences in the protein structure can cause significant changes in the efficacy and safety of these drugs. Furthermore, these large molecules are difficult to characterize without advanced instrumentation and methods. Current technologies still struggle with robustness and reproducibility. This study aims to introduce […]

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Improving the properties of active pharmaceutical ingredients by polymorph, salt and cocrystal screening

Solids exist as crystals, amorphous or subcooled liquids. The degree of crystallinity determines the long range order in a solid phase. Molecules when transferred from the solution to the solid phase may take many different crystal forms (polymorphs, solvates/hydrates, salts, co-crystals). Theoretically, there are 230 space groups describing the diversity of a crystalline material. About […]

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Characterization of Carotenogenic Heterotrophs for Production of High-Value Antioxidants

The development of novel biotechnologies will be a key component of the economic growth and development of Canada’s changing economy. A critical component of this will be fostering the development of start-up companies that can capitalize on these new opportunities. The Myera Group is an indigenous-led company in Manitoba that is developing novel biotechnologies for […]

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Development of Advanced Battery Materials for Longer Life, Higher Energy Density Lithium Ion Batteries

As lithium-ion batteries continue to expand in use, new applications such as electric vehicles have increasing demands for higher energy density and longer life batteries. Improvements beyond the industry standards will be achieved using new, innovative materials that will result in increased performance. Through this project, the intern will work on synthesis and processing new […]

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An online gauge for process analysis in the pulp industry: Integrating spectroscopic and physical measures of pulp quality to predict fitness for purpose

To sustain its leadership in the world marketplace, the Canadian pulp industry must continue to increase pulp quality, while it improves manufacturing efficiency, reduces energy consumption and decreases impact on the environment. Properties of a manufactured pulp vary with production parameters and characteristics of the feedstock. To produce pulps of the highest quality at lowest […]

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